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Thiazolidinedione (TZD) insulin sensitizers have the potential to effectively treat a number of human diseases, however the currently available agents have dose-limiting side effects that are mediated via activation of the transcription factor PPARγ. We have recently shown PPARγ-independent actions of TZD insulin sensitizers, but the molecular target of(More)
Due to its unique biology of partial sex linkage and high recombination rates, the pseudoautosomal region (PAR1) on both X and Y chromosomes has attracted considerable interest. In addition, an extremely high level of YAC instability has been observed in this region. We have derived 82 YAC clones from six different YAC libraries mapping to this 2.6-Mb(More)
Identification of a mitochondrial target of Thiazolidinedione insulin sensitizers (mTOT)— relationship to newly identified mitochondrial pyruvate carrier proteins. Abstract Thiazolidinedione (TZD) insulin sensitizers have the potential to effectively treat a number of human diseases, however the currently available agents have dose-limiting side effects(More)
BACKGROUND Genetic and developmental disruption of surfactant protein B (SP-B) expression causes neonatal respiratory distress syndrome (RDS). OBJECTIVES To assess developmental and genetic regulation of SP-B expression in vivo. METHODS To evaluate in vivo developmental regulation of SP-B, we used immunoblotting to compare frequency of detection of(More)
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