Micheline Manske

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We describe research on data-drive refinement and evaluation of a probabilistic model of student learning for an educational game on number factorization. The model is to be used by an intelligent pedagogical agent to improve student learning during game play. An initial version of the model was designed based on teachers’ advice and subjective parameter(More)
Massively parallel sequencing analyses have revealed a common mutation within the MYD88 gene (MYD88L265P) occurring at high frequencies in many non-Hodgkin lymphomas (NHLs) including the rare lymphoplasmacytic lymphoma, Waldenström's macroglobulinemia (WM). Using whole-exome sequencing, Sanger sequencing and allele-specific PCR, we validate the initial(More)
Lack of remission or early relapse remains a major clinical issue in diffuse large B-cell lymphoma (DLBCL), with 30% of patients failing standard of care. Although clinical factors and molecular signatures can partially predict DLBCL outcome, additional information is needed to identify high-risk patients, particularly biologic factors that might ultimately(More)
Shape-Free Statistical Information in Optical Character Recognition Scott Leishman Master of Science Graduate Department of Computer Science University of Toronto 2007 The fundamental task facing Optical Character Recognition (OCR) systems involves the conversion of input document images into corresponding sequences of symbolic character codes.(More)
Choosing a university or college to attend can be a daunting task. Each school has different qualities that must be taken into account and weighed against one another when making a decision. Location, cost of tuition, prestige, and size are just some of the variables that potential students take into account. The selection problem is two-fold. Firstly,(More)
Educational games are highly motivating, however, there is little evidence that they can trigger learning unless game-play is supported by additional activities. We aim to support students during game play via an intelligent pedagogical agent that intervenes to offer hints and suggestions when the student is lacking domain knowledge, but does not interfere(More)