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We report an experimental validation and applications of the new hemodynamic model presented in the companion article (Fantini, 2014-this issue) both in the frequency domain and in the time domain. In the frequency domain, we have performed diffuse optical measurements for coherent hemodynamics spectroscopy (CHS) on the brain and calf muscle of human(More)
We have investigated the amplitude and phase of spontaneous low-frequency oscillations (LFOs) of the cerebral deoxy- and oxy-hemoglobin concentrations ([Hb] and [HbO]) in a human sleep study using near-infrared spectroscopy (NIRS). Amplitude and phase analysis was based on the analytic signal method, and phasor algebra was used to decompose measured [Hb](More)
Rationale and Objectives: Perturbations in cerebral blood volume (CBV), blood flow (CBF), and metabolic rate of oxygen (CMRO 2) lead to associated changes in tissue concentrations of oxy-and deoxy-hemoglobin (DO and DD), which can be measured by near-infrared spectros-copy (NIRS). A novel hemodynamic model has been introduced to relate physiological(More)
A novel hemodynamic model has been recently introduced, which provides analytical relationships between the changes in cerebral blood volume (CBV), cerebral blood °ow (CBF), and cerebral metabolic rate of oxygen (CMRO 2), and associated changes in the tissue concentrations of oxy-and deoxy-hemoglobin (ÁO and ÁD) measured with near-infrared spectroscopy This(More)
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