Michele L. Joyner

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The increase in antibiotic resistance continues to pose a public health risk as very few new antibiotics are being produced, and bacteria resistant to currently prescribed antibiotics is growing. Within a typical hospital setting, one may find patients colonized with bacteria resistant to a single antibiotic, or, of a more emergent threat, patients may be(More)
Continuous time Markov chains are often used in the literature to model the dynamics of a system with low species count and uncertainty in transitions. In this paper , we investigate three particular algorithms that can be used to numerically simulate continuous time Markov chain models (a stochastic simulation algorithm, explicit and implicit tau-leaping(More)
In this paper, we investigate three particular algorithms: a stochastic simulation algorithm (SSA), and explicit and implicit tau-leaping algorithms. To compare these methods, we used them to analyze two infection models: a Vancomycin-resistant enterococcus (VRE) infection model at the population level, and a Human Immunodeficiency Virus (HIV) within host(More)
We consider the form of the radio-frequency (RF) or dielectric input expression in the heat equation which arises in the modeling of the curing of epoxy adhesives in bonding of composites. We review two standard derivations of a commonly used expression for the RF heating source term. In this context we discuss diiculties involving the associated inherent(More)
Ertapenem is an antibiotic commonly used to treat a broad spectrum of infections, which is part of a broader class of antibiotics called carbapenem. Unlike other carbapenems, ertapenem has a longer half-life and thus only has to be administered once a day. A physiologically-based pharmacokinetic (PBPK) model was developed to investigate the uptake,(More)
This paper introduces a computational method for use with eddy current damage detection techniques. To identify the geometry of a subsurface damage, an optimization algorithm is employed which requires solving the forward problem numerous times. In order for the method to be effective in a practical setting, i.e., in real-time applications, the forward(More)
In this paper, we develop a stochastic differential equation model to simulate the movement of a social/subsocial spider species, Anelosimus studiosus, during prey capture using experimental data collected in a structured environment. In a subsocial species, females and their maturing offspring share a web and cooperate in web maintenance and prey capture.(More)