Michele Joana Alves

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BACKGROUND AND AIMS Cachexia is a syndrome characterized by marked involuntary loss of body weight. Recently, adipose tissue (AT) wasting has been shown to occur before the appearance of other classical cachexia markers. We investigated the composition and rearrangement of the extracellular matrix, adipocyte morphology and inflammation in the subcutaneous(More)
Cancer cachexia is a multifactorial syndrome that dramatically decreases survival. Loss of white adipose tissue (WAT) is one of the key characteristics of cachexia. WAT wasting is paralleled by microarchitectural remodeling in cachectic cancer patients. Fibrosis results from uncontrolled ECM synthesis, a process in which, transforming growth factor-beta(More)
Monoclonal antibodies were raised against the surface of epimastigotes and metacylic trypomastigotes of Trypanosoma cruzi, as shown by electron microscopy, agglutination, and immunofluorescence. The antibodies were stage specific but not strain specific. A deleterious effect of the antibodies on T. cruzi culture forms was shown by the drastic reduction of(More)
Intracellular forms of Trypanosoma cruzi were destroyed in infected mouse macrophage cultures treated for 24 h with micromolar concentrations of phenazine methosulfate, brilliant cresyl blue, or crystal violet. Parasites were not killed in macrophages which were only treated with the dyes before infection, indicating that the drugs did not induce a(More)
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