Michele J. Everard

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Rapid proliferation in small cell lung cancer (SCLC) may be mediated by synthesis of autocrine growth factors. Bombesin (or its mammalian homologue gastrin releasing peptide, GRP) may have autocrine function in SCLC (Cuttitta et al., 1985; Carney et al., 1987) but is not synthesised by the faster growing variant SCLC lines (Carney et al., 1985).(More)
We have detected somatostatin receptors (SSR) by autoradiography in 3/4 established small cell lung cancer (SCLC) cell lines but not in two non-SCLC cell lines. The growth of 1/3 SSR positive SCLC cell lines was significantly inhibited by the long-acting somatostatin analogue octreotide (SMS 201-995, Sandostatin) 10(-9) M. We treated 20 SCLC patients with(More)
SCLC cell lines exhibit considerable heterogeneity as regards morphology, biochemistry and growth kinetics (Carney et al., 1985a). 'Classic' SCLC lines commonly grow as floating aggregates (morphology type I or II) and possess neuro-secretory granules (NSG) on electron microscopy. They express four biomarkers: creatine kinase-BB (CK-BB), neurone specific(More)
We showed previously that insulin-like growth factor I (IGF-I) is detectable in small cell lung cancer (SCLC) tumor biopsies and cell lines and that recombinant human IGF-I stimulates DNA synthesis in SCLC cells. Here we report further studies on the role of IGF-I in 2 SCLC cell lines: HC12, classic; and K K-Si 17. variant. Immunoreactive IGF-I was detected(More)
Analogues of the neurotransmitter substance P (SP) can interact with neuropeptide receptors, and are reported to inhibit growth of small cell lung cancer cell lines (SCLC CLs). We found [D-Arg1, D-Phe5, D-Trp7,9, Leu11] substance P (D-Phe5SP) significantly inhibited DNA synthesis by 10/10 human tumour CLs; six SCLC, one N-SCLC (squamous), two ovarian and(More)
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