Michele Gianella

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BACKGROUND Exposure to surgical smoke in the operation room has been a long-standing concern. Smoke generated by the interaction between lasers or electrocautery devices with biological tissue contains several toxic and carcinogenic substances, but only a few studies so far have provided quantitative data necessary for risk assessment. METHODS With laser(More)
In view of in vivo surgical smoke studies a difference-frequency-generation (DFG) laser spectrometer (spectral range 2900-3144 cm(-1)) and a Fourier-transform infrared (FTIR) spectrometer were employed for infrared absorption spectroscopy. The chemical composition of smoke produced in vitro with an electroknife by cauterization of different animal tissues(More)
We present a major improvement of an algorithm based on a spectral library search for the quantitative analysis of multicomponent gas samples with unknown compositions. A quantitative spectral database of infrared spectra is used as a training set to compute regression coefficients. Concentrations are computed in the principal component space via principal(More)
Transmission spectroscopy over large spectral ranges (>100 cm(-1)) generally requires a reference measurement to be taken separately from the sample scan. The ratio of the two measurements (i.e., the transmittance) is therefore susceptible to baseline changes that occur between the recording of the two spectra. The origins of relatively strong baseline(More)
BACKGROUND Dissection during laparoscopic surgery produces smoke containing potentially toxic substances. The aim of the present study was to analyze smoke samples produced during laparoscopic colon surgery using a bipolar vessel sealing device (LigaSuretrade mark). METHODS Four consecutive patients undergoing left-sided colectomy were enrolled in this(More)
To obtain further clarification of structure-activity relationships of cholinergic substances, which would give better understanding of cholinergic receptors, the carbocyclic analogs of epi-muscarine (I) and allo-muscarine (II) were prepared starting from 6-methyl-3-oxo-2-oxabicyclo[2.2.1]heptane (IV). Pharmacological tests show that these two compounds(More)
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