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Sleep spindles are a distinctive EEG phasic feature of NREM sleep and are prevalent during stage 2 as compared to slow wave sleep. While the neurophysiological mechanisms of spindle generation, that involves thalamic and corticothalamic networks, have been recently delineated and are briefly reviewed, their definitive functional meaning still remains to be(More)
Spindle density, visually scored in the 12-15 Hz range over antero-posterior midline derivations, was assessed during a baseline night in ten normal subjects. Sleep spindles were found to be highly variable between subjects and more abundant during Stage 2. Topographical distribution of spindle density showed a centroparietal prevalence, stable between NREM(More)
At a time when several studies have highlighted the relationship between sleep, learning and memory processes, an in-depth analysis of the effects of sleep deprivation on student learning ability and academic performance would appear to be essential. Most studies have been naturalistic correlative investigations, where sleep schedules were correlated with(More)
Homeostatic and circadian processes are basic mechanisms of human sleep which challenge the common knowledge of large individual variations in sleep need or differences in circadian types. However, since sleep research has mostly focused on group measures, an approach which emphasizes the similarities between subjects, the biological foundations of the(More)
Spindle activity, visually scored in the 12-15 Hz range over antero-posterior midline derivations, has been assessed in ten normal subjects during a baseline and a recovery sleep after 2 nights of selective slow-wave sleep (SWS) deprivation. The recovery sleep, characterized by a significant increase of stage 4 and SWS as compared to the baseline, revealed(More)
OBJECTIVE Electrical stimulation of the median nerve followed by a magnetic pulse on the primary motor cortex (M1) is effective to cause an increase in the amplitude of motor evoked potential (MEP) registered in the target muscle with the interstimulus interval (ISI) at 25ms (paired associative stimulation, PAS). The aim of this study is to evaluate the(More)
Humans have an individual profile of the electroencephalographic power spectra at the 8 to 16 Hz frequency during non-rapid eye movement sleep that is stable over time and resistant to experimental perturbations. We tested the hypothesis that this electroencephalographic "fingerprint" is genetically determined, by recording 40 monozygotic and dizygotic(More)
We recorded the resting electroencephalogram of 20 healthy subjects in order to investigate the effect of electromagnetic field (EMF) exposure on EEG waking activity and its temporal development. The subjects were randomly assigned to two groups and exposed, in double-blind conditions, to a typical mobile phone signal (902.40 MHz, modulated at 217 Hz, with(More)
The aim of the study was to estimate the sensitivity of a brief self-paced visual search task to increased levels of sleepiness as a consequence of 40 h of sleep deprivation. Time-of-day effects on this task, on subjective sleepiness and on oculomotor performance changes, were also assessed. Eight normal subjects slept for three nights in the laboratory(More)
Although a large body of evidence indicates that sleep plays an important role in learning and memory processes, the actual existence of a sleep-dependent spatial memory consolidation has been not firmly established. Here, by using a computerized 3D virtual navigation tool, we were able to show that topographical orientation in humans largely benefits from(More)