Michele Eatough Jones

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Cells growing in culture are subject to mutation, and as mutation is a random event, the number of mutants in a culture will be a random variable. The size of the clone of mutants arising from a single mutational event depends on the timing of the mutation; the earlier the mutation the larger the corresponding clone of mutants. The frequency with which new(More)
In estimating the spontaneous mutation rate, mu, in cultured mammalian cells, the number of mutant cells in several parallel cultures, each a clone from a single cell, is determined. Luria and Delbrück (1943), and subsequently Lea and Coulson (1949), proposed several estimators of mu using data from such experiments. These methods of analysis were(More)
When the spontaneous mutation rate mu in mammalian cell cultures is estimated using Luria-Delbrück fluctuation analysis, many factors contribute to the unreliability of the estimate. Some of these have been documented by Featherstone et al. (1987) and by Kendal and Frost (1988). In particular, the plating efficiencies for mammalian cells are often much less(More)
Although it has been speculated that ant visits to extrafloral nectaries of bracken fern may convey a fitness benefit for the plant, this has never been demonstrated with native herbivores and natural insect densities. We tested the hypothesis that ants attracted to extrafloral nectaries of bracken fern provide a mutualistic benefit by protecting fronds(More)
Dense aggregating fields of P. violaceum and P. pallidum exhibit propagated waves which may be analogous to those seen in Dictyostelium discoideum. As in D. discoideum the wave velocity is determined by an intracellular delay between stimulation and response, rather than by the diffusion coefficient of the acrasin. The frequency of the propagated wave(More)
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