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We present a quantitative model to demonstrate that coclustering multiple enzymes into compact agglomerates accelerates the processing of intermediates, yielding the same efficiency benefits as direct channeling, a well-known mechanism in which enzymes are funneled between enzyme active sites through a physical tunnel. The model predicts the separation and(More)
We introduce a random energy model on a hierarchical lattice where the interaction strength between variables is a decreasing function of their mutual hierarchical distance, making it a non-mean-field model. Through small coupling series expansion and a direct numerical solution of the model, we provide evidence for a spin-glass condensation transition(More)
We study the probability distribution of the pseudocritical temperature in a mean-field and in a short-range spin-glass model: the Sherrington-Kirkpatrick and the Edwards-Anderson (EA) model. In both cases, we put in evidence the underlying connection between the fluctuations of the pseudocritical point and the extreme value statistics of random variables.(More)
In bacteria such as Escherichia coli, DNA is compacted into a nucleoid near the cell center, whereas ribosomes-molecular complexes that translate mRNAs into proteins-are mainly localized to the poles. We study the impact of this spatial organization using a minimal reaction-diffusion model for the cellular transcriptional-translational machinery. Although(More)
If we have a system of binary variables and we measure the pairwise correlations among these variables, then the least structured or maximum entropy model for their joint distribution is an Ising model with pairwise interactions among the spins. Here we consider inhomogeneous systems in which we constrain, for example, not the full matrix of correlations,(More)
When European starlings come together to form a flock, the distribution of their individual velocities narrows around the mean velocity of the flock. We argue that, in a broad class of models for the joint distribution of positions and velocities, this narrowing generates an entropic effect that opposes the cohesion of the flock. The strength of this effect(More)
In this paper we present an approach for debugging hardware designs generated by High-Level Synthesis (HLS), relieving users from the burden of identifying the signals to trace and from the error-prone task of manually checking the traces. The necessary steps are performed after HLS, independently of it and without affecting the synthesized design. For this(More)
The large scale behavior of the simplest non-mean-field spin-glass system is analyzed, and the critical exponent related to the divergence of the correlation length is computed at two loops within the ε-expansion technique with two independent methods. The techniques presented show how the underlying ideas of the renormalization group apply also in this(More)
In a recent work [M. Castellana and G. Parisi, Phys. Rev. E 82, 040105(R) (2010)], the large-scale behavior of the simplest non-mean-field spin-glass system has been analyzed, and the critical exponent related to the divergence of the correlation length has been computed at two loops within the ε-expansion technique by two independent methods. By performing(More)