Michele Calabrese

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In the anterior pituitary gland changes in prolactin synthesis and in the incorporation of [3H]thymidine into DNA are coincident under several experimental conditions. We investigated whether these changes are obligatory, thus indicating a regulatory mechanism common to the synthesis of both macromolecules. Alternatively, the parallel changes may represent(More)
Intraoperative Avidination for Radionuclide Therapy (IART®) is a novel targeted radionuclide therapy recently used in patients with early breast cancer. It is a radionuclide approach with 90Y-biotin combined with external beam radiotherapy (EBRT) to release a boost of radiation in the tumour bed. Two previous clinical trials using dosimetry based on the(More)
Hyperprolactinaemia produced in rats by the transplanted prolactin-secreting tumours MtTW15 and 7315a significantly (P less than 0.01) inhibited by 70% the incorporation of [3H]thymidine into the pituitary DNA of the host animals. The weight and the DNA content of the glands were significantly (P less than 0.01) reduced by 30%. The administration of(More)
Angiographic evaluation of intermediate left main coronary artery stenosis (LMS) is often limited. Three-dimensional (3D) quantitative coronary angiography has recently developed to overcome 2-dimensional (2D) quantitative coronary angiographic (QCA) limitations. In patients with angiographically intermediate LMS, we investigated whether 3D quantitative(More)
We investigated the effects of lisuride, a potent dopaminergic agent, administered in vivo on the incorporation of 3H-thymidine into DNA and 3H-leucine into prolactin and its subsequent release by the rat anterior pituitary gland in vitro. The results demonstrated that daily injection of 100 micrograms of lisuride for 7 days significantly (p less than 0.05)(More)
privileged site for islet transplantation [1–3]. Rat islet allografts transplanted into the thymus of animals receiving anti-lymphocyte serum survive indefinitely, and a state of donor-specific unresponsiveness can be achieved [1]. In addition, rat islet xenografts can survive long term within the thymus of transiently immunosuppressed mice, and can promote(More)
Prolactinomas are one of the most frequent tumors of the human anterior pituitary. Dopamine agonists are the choice in the medical treatment of this disease. Bromocriptine (BC) is a well known anti-neoplasic agent in human PRL secreting adenomas although its effect on PRL cells is far from clear. We decided to investigate its influence on cell proliferation(More)
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