Michele Atkinson

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Exposure in a total knee arthroplasty can be challenging regardless of whether it is a difficult primary or a revision. Various techniques both proximal and distal to the patella have been described and implemented to gain exposure and improve knee flexion. When patella eversion is not possible due to previous surgery or severe preoperative knee flexion(More)
Herpes simplex virus amplicon vectors expressing RANTES (HSVrantes) and the T-cell costimulatory ligand B7.1 (HSVB7.1) were studied for their ability to elicit a tumor-specific T-cell response in a murine lymphoma model. HSVB7.1- and HSVrantes-transduced EL4 cells expressed high levels of B7.1 and RANTES as analyzed by flow cytometry and enzyme-linked(More)
We performed immunocytochemical staining of benign, in situ, and malignant breast disease to identify antigens related to the presence of the major parenchymal cell types of the normal breast. Markers for the epithelial cells, antiserum to epithelial membrane antigen, and three monoclonal antibodies (MAb) to milk-fat globule membranes stained most of the(More)
Type 1 diabetes is an autoimmune disease whose clinical onset signifies a lifelong requirement for insulin therapy and increased risk of medical complications. To increase the efficiency and confidence with which drug candidates advance to human type 1 diabetes clinical trials, we have generated and validated a mathematical model of type 1 diabetes(More)
OBJECTIVE To review the actions and clinical use of serum N-acetylcysteine in the critically ill patient. DATA SOURCES A review of articles published on the mechanisms of action and clinical use of N-acetylcysteine. SUMMARY OF REVIEW N-acetylcysteine (NAC) is an amino acid with a MW of 163.2. It acts as an antioxidant, both directly as a glutathione(More)
An improved medium for the isolation of Mycoplasma species from contaminated cell cultures is reported. A modification of the mycoplasma detection method using the uridine/uracil uptake ratio method is described. Results obtained using this method with mycoplasma contaminated cell cultures and with contaminated cell cultures treated with the antibiotic(More)
OBJECTIVE To review the human nutrition in the critically ill patient in a three-part presentation. DATA SOURCES Articles and published peer-review abstracts and a review of studies reported and identified through a MEDLINE search of the English language literature on parenteral nutrition. SUMMARY OF REVIEW Intravenous nutrition plays an important(More)
OBJECTIVE To review the human nutrition in the critically ill patient in a three-part presentation. DATA SOURCES Articles and published peer-review abstracts and a review of studies reported and identified through a MEDLINE search of the English language literature on parenteral nutrition. SUMMARY OF REVIEW In a healthy individual, nutrition involves an(More)