Michela Barca

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NDPase and TPPase activities were detected by histchemical techniques in the hypothalamus of rat, cat and man. Both enzymatic activities were exhibited by neurons and glial cells, the latter hydrolyzing NDP more actively than TPP. Enzyme hydrolysis of NDP and TPP was activated by imidazole and inhibited by noradrenaline, L-DOPA, L-cysteine and KF. The(More)
The presence of mutations in the KRAS gene is a predictor of a poor clinical response to EGFR-targeted agents in patients affected by colorectal cancer (CRC), but its significance as a global prognostic factor remains unclear. The aim of the present study was to evaluate the impact of the KRAS mutational status on time to first metastasis (TTM) and overall(More)
Activation of oncogenes downstream the EGFR gene contributes to colorectal tumorigenesis and determines the sensitivity to anti-EGFR treatments. The aim of this study was to evaluate the prognostic value of KRAS, BRAF, NRAS and PIK3CA mutations in a large collection of CRC patients from genetically-homogeneous Sardinian population. A total of 1284 Sardinian(More)
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