Michel Perrut

Learn More
Astaxantine from the microalga Haematococcus pluvialis and phycocyanine from the microalga Spirulina maxima have been obtained by supercritical extraction using carbon dioxide. Prior to extraction, the samples of microalgae were crushed by cutting mills (coffee mill) and then manually ground with dry ice (solid carbon dioxide). The Haematococcus extracts(More)
Myristic acid esterification has been performed by an immobilized lipase from Mucor Miehei both in n-hexane and in supercritical carbon dioxide (SCCO(2)). The enzyme is stable in SCCO(2) at 15 MPa and 323 K. The reaction rate is influenced by the concentration of water and by the reaction medium composition. A reaction mechanism is proposed, and kinetic(More)
The solid state morphology of many compounds is a key-parameter for their further utilization when several forms can co-exist either as crystalline and amorphous, and/or as different polymorphs (allotropes) ; this is particularly important for pharmaceutical drugs as their morphology can have a significant impact on their bio-availability and stability.(More)
As a growing number of new active compounds exhibit a very low solubility in biological media, the pharmaceutical industry is facing a major challenge to find routes to formulate such compounds in order to reach an “acceptable” bio-availability [1]: More than one third of the drugs listed in the US Pharmacopoeia are considered as poorly-soluble, and a(More)
Generation of various types of particles (nano-, micro-, neat or composite particles) for pharmaceutical applications is focusing significant R&D efforts worldwide. However, most works are completed on small-scale equipment, leading to attractive results that only demonstrate the process feasibility without any evaluation of scale-up issues. At the(More)
As Nature is almost an unlimited source of active substances, a great interest is paid to concentrate them or to remove undesired compounds, using mainly extraction with organic solvents or water or ethanol/water mixtures, depending on the polarity of the targeted molecules. However, for the past three decades, important R&D works about supercritical fluid(More)
In general, aerogels are prepared from gels, which in turn can be produced from organic monomers for organic aerogels and from inorganic salts or metal alkoxydes for inorganic aerogels [1]. In the preparation of the gels, a first step is the preparation of a colloidal form of the material or Sol, which is called an “aquasol” if the liquid phase is water,(More)
Among the hundreds of articles dealing with SCF particle design [3-5], it is rather surprising that very few ones disclosed interesting results on dissolution-rate comparison between the unprocessed material and the SCF micronized solid, as detailed below ; moreover, in most publications, data are not complete and physical properties of the solid material(More)
  • 1