Michel Paquette

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Chromatin rearrangements occur during repair of cyclobutane pyrimidine dimers (CPDs) by nucleotide excision repair (NER). Thereafter, the original structure must be restored to retain normal genomic functions. How NER proceeds through nonnucleosomal chromatin and how open chromatin is reestablished after repair are unknown. We analyzed NER in ribosomal(More)
UNLABELLED The purpose of this study was to evaluate the effects of 2 anesthetic agents on myocardial perfusion and coronary reserve in rats under resting and stress conditions with small animal PET. METHODS Twenty-four rest/stress studies were performed in 6 rats. Each animal received all 4 possible combinations of anesthetic agents (propofol,(More)
INTRODUCTION The purpose of this study was to develop a noninvasive model in tumor-bearing mice to investigate the use of 16α-[(18)F]fluoro-17β-estradiol (FES) positron emission tomography (PET) imaging as a tool to discriminate between tumors having different estrogen receptor (ER) α status. METHODS MC7-L1 and MC4-L2 murine mammary adenocarcinoma cell(More)
The chromatin structure of RNA polymerase I--transcribed ribosomal DNA (rDNA) is well characterized. In most organisms, i.e., lower eukaryotes, plants, and animals, only a fraction of ribosomal genes are transcriptionally active. At the chromatin level inactive rDNA is assembled into arrays of nucleosomes, whereas transcriptionally active rDNA does not(More)
A Boolean value of given a priori probability distribution is transmitted to a deciding agent by several processes. Each process fails independently with given probability, and faulty processes behave in a Byzantine way. A deciding agent has to make a decision concerning the transmitted value on the basis of messages obtained by processes. We construct a(More)
We consider the problem of removing c points from a set S of n points so that the remaining point set is optimal in some sense. Definitions of optimality we consider include having minimum diameter, having minimum area (perimeter) bounding box, having minimum area (perimeter) convex hull. For constant values of c, all our algorithms run in O(n log n) time.
We construct and analyze a fast broadcasting algorithm working in the presence of Byzantine component faults. Such faults are particularly difficult to deal with, as faulty components may behave arbitrarily (even maliciously) as transmitters, by either blocking, rerouting, or altering transmitted messages in a way most detrimental to the broadcasting(More)
The aim of this paper is to study communication in networks where nodes fail in a random dependent way. In order to capture fault dependencies, we introduce the neighborhood fault model, where damaging events, called spots, occur randomly and independently with probability p at nodes of a network, and cause faults in the given node and all of its neighbors.(More)
Nucleotide excision repair (NER) removes a plethora of DNA lesions. It is performed by a large multisubunit protein complex that finds and repairs damaged DNA in different chromatin contexts and nuclear domains. The nucleolus is the most transcriptionally active domain, and in yeast, transcription-coupled NER occurs in RNA polymerase I-transcribed genes(More)
We consider the problem of locating a black hole in a synchronous , anonymous, and unoriented torus network using mobile agents. A black hole is a harmful network node that destroys any agent visiting it without leaving any trace. The objective is to locate the black hole using as few agents as possible. We present here an almost optimal deter-ministic(More)