Michel Leroy

Learn More
BACKGROUND Overuse of antibiotics is the main force driving the emergence and dissemination of bacterial resistance in the community. France consumes more antibiotics and has the highest rate of beta-lactam resistance in Streptococcus pneumoniae than any other European country. In 2001, the government initiated "Keep Antibiotics Working"; the program's main(More)
1. Lithium is known to affect thyroid function. It can cause both subclinical and overt hypothyroidism that may involve in some instances an autoimmune mechanism. 2. Sixty (60) psychiatric patients, already under treatment with lithium for at least 6 months, were administered additional thyroid tests and monitored over a one-year period to study the(More)
OBJECTIVE The objective of this study was to evaluate occupations associated with a high risk of specific chronic diseases in self-employed workers. METHODS For each occupational category and gender, the observed and expected numbers of prevalent cases for each chronic disease leading to exemption from copayments by the French National Health Insurance(More)
BACKGROUND Depression after acute coronary syndromes (ACS) is an important risk factor for further coronary events; but the influence of anhedonia, the decreased capacity to experience pleasure, has received little attention. The aim of the study was to investigate the effects of anhedonia on prognosis at 3-year follow-up in patients hospitalized for ACS.(More)
Our aim was to evaluate a type 3 portable simplified device as a screening tool for obstructive sleep apnoea (OSA) in coronary patients. In 50 patients selected independently from sleep complaints, we compared the number of respiratory events per hour of valid recording time counted automatically by the device and the number counted manually per hour of(More)
Fibrates are widely used as lipid lowering drugs acting as peroxisome proliferator-activated receptors α (PPARα) agonists and modulating the expression of several genes involved in lipid and lipoprotein metabolism. Much less is known on the effect of fibrates in HDL structure and composition. Therefore, we examined whether fenofibrate induces quantitative(More)
OBJECTIVE Several depressive symptoms increase the risk of adverse clinical events after acute coronary syndrome (ACS) but the potential effect of impulsivity has not been explored. The aim of the study was to investigate the effects of impulsivity on prognosis at 3-year follow-up in patients hospitalised for ACS. METHODS Consecutively admitted ACS(More)
  • 1