Michel Krämer

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Over the last years, a high demand for scenario-specific visualizations of 3D urban models has evolved. At the same time, established service specifications do not yet provide the means to define 3D map products and to deliver them in suitable formats, since they are focused on traditional 2D map products. In this paper, we present an approach for the(More)
The comparative tumorigenicity in rats and nude mice of cell lines derived from FR3T3 and transformed by either c-jun, ras, SV40 lt, or bovine papilloma virus type 1 (BPV1) oncogenes was investigated. c-Jun-transformed cells were as tumorigenic and metastatic as Ras-transformed cells. Latencies were short, and numerous pulmonary metastases were observed in(More)
The CC-chemokine regulated on activation, normal T-cell expressed, and presumably secreted (RANTES)/CCL5 mediates its biological activities through activation of G protein-coupled receptors, CCR1, CCR3, or CCR5, and binds to glycosaminoglycans. This study was undertaken to investigate whether this chemokine is involved in hepatoma cell migration or invasion(More)
In this paper we present a web-based platform that makes use of HTML5 technology and WebGL to facilitate public participation in urban planning. It consists of components that enable city administrations to present urban plans to the public and to engage with stakeholders. One of these components uses the open source library X3DOM to visualise 3D(More)
We investigated the effect of a new dextran derivative, phenylacetate carboxymethyl benzylamide dextran (NaPaC), on epidermoid carcinoma A431 cells secreting a large quantity of angiogenic factor, vascular endothelial growth factor (VEGF). In vitro, NaPaC inhibited the proliferation of A431 cells (IC(50)=5 micro M). Also, NaPaC decreased the binding of(More)
Vascular endothelial growth factor (VEGF) expression is elevated in a wide variety of solid tumours. Inhibition of VEGF activities is able to reduce angiogenesis and tumour growth. We have recently shown in vitro that carboxymethyl dextran benzylamide (CMDB7) prevents the binding of VEGF(165) to its cell surface receptors and thus inhibits VEGF activities(More)
Sodium phenylacetate (NaPa) and carboxymethyl benzylamide dextran derivative (CMDB(LS4)) are able to inhibit growth of breast tumour cells. In this study, we explored whether the combination of NaPa and CMDB(LS4)may enhance their respective inhibitory effects on the MCF-7ras cell growth in vitro and in vivo. NaPa inhibited MCF-7ras cell proliferation by(More)
In this paper a new user interface for the processing of big geospatial data in the Cloud is presented. The paper focuses on the processing of Smart City data since this kind of data is inherently large and becomes more and more important for the maintenance and planning of sustainable future Smart Cities. The user interface is facilitated by(More)