Michel H. P. Hof

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BACKGROUND To investigate whether biomarkers consisting of baseline characteristics of advanced stage ovarian cancer patients can help in identifying subgroups of patients who would benefit more from primary surgery or neoadjuvant chemotherapy. METHODS We used data of the European Organisation for Research and Treatment of Cancer (EORTC) 55971 trial in(More)
STUDY QUESTION What is the time to conception in a cohort of women with unexplained recurrent miscarriage (RM). SUMMARY ANSWER Median time to conception in women diagnosed with unexplained RM was 21 weeks (interquartile range (IQR) 8-55 weeks), with a cumulative incidence of conception of 74% after 12 months of trying to conceive. WHAT IS KNOWN ALREADY(More)
OBJECTIVE To compare the difference in risks of neonatal and maternal complications, including uterine rupture, in a second birth following a planned caesarean section versus emergency caesarean section in the first birth. DESIGN Prospective cohort study. SETTING Population-based cohort in the Netherlands. POPULATION Linked data set of outcomes for(More)
OBJECTIVE To investigate whether vaginal Group B Streptococcus (GBS) colonisation or other baseline characteristics of women with preterm premature rupture of membranes (PPROM) can help in identifying subgroups of women who would benefit from immediate delivery. DESIGN Secondary analysis of the PPROMEXIL trials. SETTING Sixty hospitals in the(More)
BACKGROUND Malignant endocrine tumours (MET) are rare neoplasms in childhood and data on such tumours are scarcely available. The aim of this retrospective study was to collect data over a period of 11 years (1984-1995) and to give the basis for a prospective study. PATIENTS AND METHOD 180 departments of paediatrics, nuclear medicine and children's(More)
INTRODUCTION The development of overweight is often measured with the body mass index (BMI). During childhood the BMI curve has two characteristic points: the adiposity rebound at 6 years and the BMI peak at 9 months of age. In this study, the associations between the BMI peak and body composition measures and blood pressure at age 5-6 years were(More)
BACKGROUND Some recently emerged lipid-lowering therapies are currently restricted to patients with homozygous familial hypercholesterolemia (HoFH), and studies are underway to also assess these therapies in patients with 'severe heterozygous FH (HeFH)'. However, no uniform definition of 'severe HeFH' exists, although untreated low-density lipoprotein(More)
BACKGROUND In the Netherlands separate reference charts have been developed for native and immigrant groups to deal with differences in growth patterns in later childhood. The use of these charts, however, is complicated by methodological issues; they do not represent all large Dutch immigrant groups in separate charts despite the differences that have been(More)
OBJECTIVE To determine the risk of preterm birth in a subsequent twin pregnancy after previous singleton preterm birth. DESIGN Cohort study. SETTING Nationwide study in the Netherlands. POPULATION In all, 4071 nulliparous women who had a singleton delivery followed by a subsequent twin delivery between the years 1999 and 2007 were studied. METHODS(More)
BACKGROUND In newborn the finding of adrenal gland hemorrhage is not uncommon. Only few cases of prenatal diagnosis of fetal adrenal bleeding by sonography have been reported. CASE In a 28-year-old nulliparous pregnant woman, routine sonography performed in 35 + 2 weeks of gestational age showed a cystic mass on the upper pole of the right kidney of a(More)