Michel H . Lefebvre

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OBJECTIVE To describe environmental contamination with hazardous drugs in a hospital pharmacy setting before and after reorganizing a hematology- oncology satellite pharmacy. METHODS This is a descriptive study of surface contamination with cyclophosphamide, ifosfamide, and methotrexate in two hematology-oncology satellite pharmacies. In order to measure(More)
OBJECTIVE Evaluate contamination on the external surfaces of cyclophosphamide vials available on the Canadian market during storage in pharmacy departments and the efficacy of decontaminating the external surfaces of vials using various cleaning techniques. METHODS The study consisted of three phases: the quantification of cyclophosphamide on the external(More)
We report on a nested-cavity, doubly resonant optical parametric oscillator (NesCOPO) architecture for widely tunable, mid-IR, single-frequency generation. By use of an achromatic phase-adapted double-pass pumping scheme, this new, low-threshold, semimonolithic architecture only requires two free-standing cavity mirrors and a nonlinear crystal with a mirror(More)
OBJECTIVE Compare the efficacy of the cleaning technique usually employed in our healthcare facility to eliminate environmental contamination with cyclophosphamide with that of the Surface Safe commercial kit. METHODS This is a three-step evaluative and comparative study involving: (i) the voluntary contamination of the surface of a hood with a(More)
PURPOSE No occupational exposure limit exists for antineoplastic drugs. The main objective of this study was to describe environmental contamination with cyclophosphamide, ifosfamide and methotrexate in pharmacy and patient care areas of Canadian hospitals in 2012. The secondary objective was to compare the 2012 environmental monitoring results with the(More)
OBJECTIVES To evaluate environmental contamination with methotrexate, cyclophosphamide, and ifosfamide in Quebec, Canada, community pharmacies and to describe hazardous drug handling practices in these pharmacies. METHODS Three standardized sites were sampled in each participating community pharmacy. Samples were analyzed for the presence of(More)
BACKGROUND Since publication of the US National Institute for Occupational Safety and Health alert on hazardous drugs in 2004, many health care organizations have reviewed their procedures for handling hazardous drugs. Occupational exposure may occur when handling, compounding, or administering a drug considered to be hazardous, at any stage from storage to(More)
BACKGROUND Case series of ingestion in preschool children may include patients without significant exposure if the substance is not measured. METHODS In order to evaluate the unproven ingestion bias, we conducted, between January 2000 and June 2004, a retrospective analysis of a poison control center-based series of children <6 years old with a history of(More)
BACKGROUND Inuit women from Northern Québec have been shown to consume inadequate quantities of vitamin A. This study was conducted to evaluate the prevalence of blood vitamin A deficiency in newborns from 3 distinct populations of the province of Québec. METHODS 594 newborns were included in this study (375 Inuit newborns from northern Québec (Nunavik),(More)