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Extended-synaptotagmin-2 mediates FGF receptor endocytosis and ERK activation in vivo.
TLDR
It is shown that the synaptotagmin-related membrane protein E-Syt2 is essential for rapid endocytosis of the activated FGF receptor and for functional signal transduction during Xenopus development and a broader role for the E- Syt subfamily in growth factor signaling is suggested. Expand
A unique enhancer boundary complex on the mouse ribosomal RNA genes persists after loss of Rrn3 or UBF and the inactivation of RNA polymerase I transcription
TLDR
A poised state of rDNA chromatin is defined and the Enhancer Boundary Complex is found as the likely entry point for chromatin remodelling complexes, which not only delimits each functional rRNA gene, but also is stably maintained after gene inactivation and the re-establishment of surrounding repressive chromatin. Expand
Loss of Extended Synaptotagmins ESyt2 and ESyt3 does not affect mouse development or viability, but in vitro cell migration and survival under stress are affected
TLDR
Mouse lines carrying homozygous deletions in one or both of the genes encoding the highly homologous ESyt2 and Esyt3 proteins are generated and Surprisingly, esyt2+/−/esyt3−/− mice develop normally and are both viable and fertile. Expand
Depletion of the cisplatin targeted HMGB-box factor UBF selectively induces p53-independent apoptotic death in transformed cells
TLDR
It is found that cisplatin in fact induces a very rapid displacement of UBF from the ribosomal RNA genes and strong inhibition of ribosome biogenesis, consistent with this being an important factor in its cytotoxicity. Expand
The chromatin landscape of the ribosomal RNA genes in mouse and human
TLDR
An alternative model for the active rRNA gene chromatin is suggested and how this structure is determined and maintained is discussed. Expand
Conditional Inactivation of Upstream Binding Factor Reveals Its Epigenetic Functions and the Existence of a Somatic Nucleolar Precursor Body
TLDR
It is shown that UBF is essential for embryo development beyond morula and that it defines the active chromatin conformation of both gene and enhancer sequences, and arrest of rRNA synthesis does not suppress transcription of the 5S, tRNA or snRNA genes, nor expression of the several hundred mRNA genes implicated in ribosome biogenesis. Expand
Loss of all 3 Extended Synaptotagmins does not affect normal mouse development, viability or fertility
TLDR
It is shown that E-Syt1 is specifically expressed throughout the embryonic skeleton during the early stages of chrondrogenesis in a pattern quite distinct from that of E- Syt2 or 3, suggesting that they may only provide a survival advantage under specific conditions that have as yet to be identified. Expand
The cellular abundance of the essential transcription termination factor TTF-I regulates ribosome biogenesis and is determined by MDM2 ubiquitinylation
TLDR
Both the sub-nuclear localization and the abundance of TTF-I are key regulators of ribosome biogenesis, strongly suggesting that exact T TF-I levels are critical for efficient ribosomal RNA synthesis and processing. Expand
Identification of Cellular Processes That Are Rapidly Modulated in Response to Tracheal Occlusion Within Mice Lungs
TLDR
It is concluded that intraluminal stretch increase during prealveolar stage of lung development induces a critical transition of pulmonary cells phenotype in which there is an increase in α-smooth muscle actin (α-SMA)–containing cells along with a relative decrease in lipid-containing cells. Expand
A recurrent de novo missense mutation in UBTF causes developmental neuroregression
TLDR
Patients with very similar patterns of neuroregression due to recurrent de novo mutations in UBTF (GRCh37/hg19, NC_000017) are described, characterized by slow progression of global motor, cognitive and behavioral dysfunction. Expand
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