Michel Dehan

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The dramatic improvement in neonatal care during the last decade did not succeed in reducing the incidence of periventricular leukomalacia (PVL), suggesting that prenatal events may be the main target for PVL prevention. The studied cohort included 753 very preterm infants born between 24 and 32 weeks of gestational age, admitted to the intensive care unit(More)
OBJECTIVE To estimate the prevalence of cerebral palsy at 2 years of age among children born very preterm, according to gestational age, infant gender, plurality, and neonatal cranial ultrasound abnormalities. METHODS All infants born between 22 and 32 weeks of gestation in 9 regions of France in 1997 were included in this prospective, population-based,(More)
OBJECTIVE To describe the outcome of pregnancies conceived by IVF and the follow-up of the children after a minimum of 1 year of life. DESIGN Survey of clinical pregnancies and follow-up of the children and comparison with national statistics. SETTINGS All clinical pregnancies from 11 French centers between January 1987 and June 1989. PATIENTS A total(More)
OBJECTIVE To analyze the main clinical features, genetic mutations, and outcomes of patients of the French Congenital Central Hypoventilation Syndrome (CCHS) Registry. DESIGN A country-wide cohort established throughout a long-term multicenter effort. PATIENTS Seventy French patients with CCHS (29 male patients and 41 female patients). METHODS The(More)
OBJECTIVES To test the association between cytokine levels in the amniotic fluid and (i) the vascular invasion phase of intrauterine infection, (ii) the occurrence of periventricular leukomalacia; to assess the correlation between C-reactive protein levels, a recognised biological marker of inflammation in maternal serum and cytokine levels in the amniotic(More)
BACKGROUND Antenatal glucocorticoid therapy decreases the incidence of several complications among very premature infants. However, its effect on the occurrence of cystic periventricular leukomalacia, a major cause of cerebral palsy, remains unknown. METHODS We retrospectively analyzed a cohort of 883 live-born infants, with gestational ages ranging from(More)
OBJECTIVE To identify factors influencing the outcome of premature infants delivered after prolonged premature rupture of membranes before 25 weeks' gestation. DESIGN AND POPULATION All premature infants with gestational age <34 weeks, either inborn or outborn, with history of rupture of membranes before 25 weeks' gestation, admitted to our NICU between(More)
OBJECTIVE To evaluate the outcome for all infants born before 33 weeks gestation until discharge from hospital. DESIGN A prospective observational population based study. SETTING Nine regions of France in 1997. PATIENTS All births or late terminations of pregnancy for fetal or maternal reasons between 22 and 32 weeks gestation. MAIN OUTCOME MEASURE(More)
OBJECTIVE To develop and validate a scale suitable for use in clinical practice as a tool for assessing prolonged pain in premature infants. METHODS Pain indicators identified by observation of preterm infants and selected by a panel of experts were used to develop the EDIN scale (Echelle Douleur Inconfort Nouveau-Né, neonatal pain and discomfort scale).(More)
Embryo cryopreservation is routinely used in in-vitro fertilization (IVF)-embryo transfer programmes. Yet very few studies have reported the follow-up of children conceived with frozen/thawed embryos. This study was designed to follow up the total cohort of children conceived with cryopreserved embryos in A. Béclère Hospital in Clamart, France between 1986(More)