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BACKGROUND This study aimed to calculate costs and health-related quality of life of women with endometriosis-associated symptoms treated in referral centres. METHODS A prospective, multi-centre, questionnaire-based survey measured costs and quality of life in ambulatory care and in 12 tertiary care centres in 10 countries. The study enrolled women with a(More)
STUDY OBJECTIVE To compare the frequency of complications of total laparoscopic hysterectomy performed in the first and more recent years of our experience, and based on that, offer ways to prevent them. DESIGN Retrospective, comparative study (Canadian Task Force classification II-2). SETTING University tertiary referral center for endoscopic surgery.(More)
Endometriosis, a common gynecological disorder that causes infertility and pelvic pain, is defined as the presence of endometrial glands and stroma within extra-uterine sites. However, despite extensive studies its etiology and pathogenesis are not completely understood. Differentially expressed genes were investigated in epithelial and stromal cells from(More)
OBJECTIVE To investigate differentially expressed genes in epithelial and stromal cells of eutopic endometrium from patients with deep endometriosis and women with normal pelvic cavities using laser capture microdissection and complementary DNA microarrays. DESIGN Prospective study. SETTING University hospital. PATIENT(S) Patients with deep(More)
OBJECTIVE To compare tumor growth, intraperitoneal implantation, and abdominal wall metastasis after laparotomy and CO2 pneumoperitoneum in a rat ovarian cancer model. METHODS To mimic intraoperative rupture of an ovarian tumor in a syngenic rat ovarian carcinoma model, 10(5) malignant cells were injected intraperitoneally after a 5-cm vertical midline(More)
Endometriosis is a multifactorial disease with possible genetic predisposition and involvement of environmental factors in its pathogenesis. The genetic polymorphism of glutathione S-transferase M1 (GSTM1) gene, which codes for glutathione S-transferase 1, class mu foreign compound conjugating enzyme of phase II detoxification system, was studied by(More)
OBJECTIVE To assess ovarian cortex surrounding benign ovarian cysts after cryopreservation and grafting to severe combined immunodeficient (SCID) mice. DESIGN Animal study. SETTING Academic research laboratories. PATIENT(S) Ovarian tissue obtained from 15 patients. INTERVENTION(S) Grafting of fresh and frozen/thawed ovarian tissue into the(More)
STUDY OBJECTIVE To evaluate feasibility and anatomic and functional results of complete laparoscopic treatment of genital prolapse with meshes. DESIGN Retrospective monocentric study (Canadian Task Force classification II-2). SETTING Centre Hospitalier Universitaire de Clermont-Ferrand, Polyclinique Hôtel Dieu, France. PATIENTS One hundred(More)
OBJECTIVE To evaluate fertility results after laparoscopic distal tuboplasty and to compare these results with those obtained previously with microsurgery. DESIGN Retrospective, nonrandomized. SETTING Department of Obstetrics and Gynecology at the University Hospital of Clermont-Ferrand, France. PATIENTS All the distal tuboplasties performed between(More)
OBJECTIVE to evaluate the complications after surgery for deep endometriosis. DESIGN retrospective study. SETTING data from the CHU Estaing database and patients' charts between January 1987 and December 2007. SAMPLE all women given surgical treatment for deep endometriosis. METHODS women who underwent surgery for deep endometriosis were reviewed(More)