Michel C F Shamy

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Impaired consciousness requires altered cortical function. This can occur either directly from disorders that impair widespread bilateral regions of the cortex or indirectly through effects on subcortical arousal systems. It has therefore long been puzzling why focal temporal lobe seizures so often impair consciousness. Early work suggested that altered(More)
Noreen Kamal, PhD, PEng; Michael D. Hill, MD, MSc, FRCPC; Dylan P.V. Blacquiere, MD, MSc, FRCPC; Jean-Martin Boulanger, MD, FRCPC; Karl Boyle, MB, BCh, BAO, MRCPE, MSc (Stroke Med); Brian Buck, MD, FRCPC; Kenneth Butcher, MD, FRCPC; Marie-Christine Camden, MD, FRCPC; Leanne K. Casaubon, MD, MSc, FRCPC; Robert Côté, MD, FRCPC; Andrew M. Demchuk, MD, FRCPC;(More)
Tardive dyskinesia (TD) is a serious adverse effect often associated with the first generation antipsychotic medications used in the management of mental health disorders such as schizophrenia. Pharmacogenomics is the study of human genomic variation in relation to individual and population variability in medication response and side effects.(More)
Recent developments in our understanding of psychogenic movement disorders have not yet led to advances in treatment. A potentially beneficial treatment strategy is suggestion, the voluntary use by the physicians of techniques that introduce into the patient's mind a belief that he or she will be healed. Principalism, the dominant school of contemporary(More)
On February 11, 2015, the Canadian Food Inspection Agency announced that a cow born and raised in Alberta had tested positive for bovine spongiform encephalopathy (BSE), commonly known as mad cow disease. BSE is a prion disease of cattle that, when transmitted to humans, produces a fatal neurodegenerative disease known as variant Creutzfeldt-Jakob disease.(More)
OBJECTIVE We hypothesized that low rates of tissue plasminogen activator (tPA) use are only partially explained by medical considerations, and that biases, beliefs, systems, and uncertainty affect acute stroke decision-making. METHODS We generated a list of factors potentially influential in acute stroke decision-making: uncertainty, patient demographics(More)
Chemical interaction is of major concern in the assessment of risk by regulatory agencies. In the present study, treatment of human lymphocytes with NiSO4 (1-100 microM) or UV-light (200, 1000 ergs/mm2) induced micronuclei (MN) in a dose-dependent fashion. Statistical analysis of the interaction factor (IF), showed that combined treatments of Ni(II) (1-100(More)
The ethical principle of 'equipoise', introduced in 1974, represents the most widely influential justification for the enrollment of patients into randomized clinical trials. However, definitions of equipoise vary, and its terms are not universally accepted. In this paper, we suggest a new way of approaching the ethics of clinical trial enrollment, which we(More)