Michel-Ange Morales

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We studied the effect of dopamine (DA) on the rate of processing of PRL after biosynthesis and, with TRH, on the secretion of PRL of different intracellular ages. In these studies anterior pituitary (AP) PRL of lactating rats was pulse labeled either in vivo with [3H]leucine (3 microCi/g BW, injected iv 0.2, 1, 4, 8, 16, or 24 h before removing the AP for(More)
PRL transformation involves a dopamine (DA)-controlled, thiol-mediated decrease in pituitary PRL detectability that precedes and may determine increased PRL release. The present studies were designed to determine 1) whether structural changes occur to adenohypophyseal (AP) PRL during in vitro transformation and may account for decreased PRL detectability;(More)
OBJECTIVE To assess the effect of a Crew Resource Management (CRM) intervention specifically designed to improve teamwork and communication skills in a multidisciplinary obstetrical setting. METHOD Design--A before-and-after cross-sectional study designed to assess participants' satisfaction, learning and change in behaviour, according to Kirkpatrick's(More)
Recent observations have shown that in lactating rats previously deprived of suckling, either suckling stimulus or ip injection of norepinephrine was capable of increasing mammary deiodinase type 1 (M-D1) mRNA content and enzyme activity. In the present work, we show that intact efferent sympathetic mammary innervation is required to restore both mammary D1(More)
We injected, i.e., intracerebroventricularly (ICV) or systematically, small amounts of adrenaline (ADR), noradrenaline (NA), isoproterenol (ISOP) and dopamine (DA) in urethane-anesthetized lactating rats, and determined the effects on isometrically recorded intramammary pressure (IMP) responses to exogenous oxytocin (OXY). While centrally administered ADR,(More)
The hypothesis that catecholamines may be released by mammary gland stimulation during lactation was tested by measuring, with an HPLC electrochemical method, plasma epinephrine (E) and norepinephrine (NE) concentrations during suckling in conscious rats and during electrical stimulation (pulses: 1 msec duration, 10/sec at 5-30 V) of the central end of a(More)
Depletion-transformation of PRL is a decrease in tissue PRL detectability which precedes and may often be required for increased PRL release. The present studies were designed to determine whether thiol-disulfide interchange mechanisms may be involved in PRL transformation and release by the pituitary of the lactating rat. Thirds of 8-h nonsuckled lactating(More)