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A high-performance data path to implement digital signal processing (DSP) kernels is introduced in this paper. The data path is realized by a flexible computational component (FCC), which is a pure combinational circuit and it can implement any 2 times 2 template (cluster) of primitive resources. Thus, the data path's performance benefits from the(More)
Insulin-like growth factor-binding protein-3 (IGFBP-3) is a member of a family of structurally conserved proteins (IGFBP-1 to -6) which act as carriers and regulators of the mitogenic peptide hormones IGF-I and IGF-II. Members of the IGFBP family share conserved cysteine-rich amino- and carboxyl-terminal regions. The amino-terminal domain of these proteins(More)
A recombinant hydroxylated fragment of human type III collagen has been produced in Saccharomyces cerevisiae by coordinated coexpression of a collagen gene fragment together with both the alpha- and beta-subunit genes for prolyl-4-hydroxylase (EC 1.14.11.2). The collagen fragment consisted of 255 residues of the helical domain and the complete C-telopeptide(More)
Each of three conserved positively-charged residues in the C-terminal region of subunit 8 of yeast (Saccharomyces cerevisiae) mitochondrial ATP synthase was replaced with isoleucine. The assembly and functional properties of the resulting variants (substituted at Arg-37, Arg-42 and Lys-47) were examined using in-vitro systems to assay import into isolated(More)
In this paper, a high-performance reconfigurable coarse-grain data-path, part of a hybrid reconfigurable platform, is introduced. The data-path consists of coarse-grain components that their flexibility and universality is shown to increase the system's performance due to significant reductions in latency. A methodology of unsophisticated but efficient(More)
A partitioning methodology between the reconfigurable hardware blocks of different granularity, which are embedded in a generic heterogeneous architecture, is presented. The fine-grain reconfigurable logic is realized by an FPGA unit, while the coarse-grain reconfigurable hardware by a 2-Dimensional Array of Processing Elements. Critical parts, called(More)
In this paper, we present performance results from mapping five real-world DSP applications on an embedded system-on-chip that incorporates coarse-grain reconfigurable logic with an instruction-set processor. The reconfigurable logic is realized by a 2-dimensional array of processing elements. A mapping flow for improving application's performance by(More)
A series of mitochondrially inherited mutants of yeast has been analysed, which were previously identified as showing resistance to the antibiotics venturicidin or ossamycin and whose mutations showed tight linkage to oligomycin-resistance alleles affecting subunit 9 of the mitochondrial ATP synthase. DNA sequence analysis of the oli1 gene of these mutants(More)
We describe a novel method for enhancing protein import into mitochondria, by tandemly duplicating the N-terminal cleavable leader peptide using a gene manipulation strategy. The import into isolated yeast mitochondria of passenger proteins (yeast mitochondrial ATP synthase subunits 8 and 9 and some mutagenised derivatives) that show little or no import(More)