Michal Or-Guil

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We introduce a new model for the dynamics of centroblasts and centrocytes in a germinal center. The model reduces the germinal center reaction to the elements considered as essential and embeds proliferation of centroblasts, point mutations of the corresponding antibody types represented in a shape space, differentiation to centrocytes, selection with(More)
A fundamental property of cell populations is their growth rate as well as the time needed for cell division and its variance. The eukaryotic cell cycle progresses in an ordered sequence through the phases G1, S, G2, and M, and is regulated by environmental cues and by intracellular checkpoints. Reflecting this regulatory complexity, the length of each(More)
Peptide arrays prepared by the SPOT synthesis technology have emerged as a proteomic tool to study molecular recognition and identify biologically active peptides. However, it was previously not clear how accurately signal intensities obtained by probing peptide arrays for protein binding really reflect the dissociation constants of the protein-peptide(More)
Germinal centers (GCs) are complex, multicell-type, transient structures that form in secondary lymphatic tissues in response to T cell-dependent stimulation. This process is crucial to the adaptive immune response because it is the source of affinity maturation and long-lived B cell memory. Our previous studies showed that the growth of murine splenic GCs(More)
The proteasome is the major protease for intracellular protein degradation. The influx rate of protein substrates and the exit rate of the fragments/products are regulated by the size of the axial channels. Opening the channels is known to increase the overall degradation rate and to change the length distribution of fragments. We develop a mathematical(More)
BACKGROUND Different immunotherapy approaches for the treatment of cancer and autoimmune diseases are being developed and tested in clinical studies worldwide. Their resulting complex experimental data should be properly evaluated, therefore reliable normal healthy control baseline values are indispensable. METHODOLOGY/PRINCIPAL FINDINGS To assess intra-(More)
The dispersion relation is the dependence of the velocity of periodic planar wave trains on their wavelength. We study the occurrence of a velocity gap in the dispersion relation in a bistable three component reaction-diffusion system modeling intracellular Ca2+ dynamics. In two spatial dimensions, localized pinned spirals are observed, if their wavelength(More)
1 Systems Immunology Laboratory, Department of Biology, Humboldt-Universität zu Berlin, Berlin, Germany 2 Research Center ImmunoSciences, Charité-Universitätsmedizin Berlin, Berlin, Germany 3 Area of Immunology, Faculty of Biology, Biomedical Research Center (CINBIO), Universidade de Vigo, Vigo, Spain 4 Instituto Biomédico de Vigo, Vigo, Spain 5 Instituto(More)
Personalized medicine is promising a revolution for medicine and human biology in the 21st century. The scientific foundation for this revolution is accomplished by analyzing biological high-throughput data sets from genomics, transcriptomics, proteomics, and metabolomics. Currently, access to these data has been limited to either rather simple Web-based(More)
Human and murine humoral immune responses are associated with changes of both the composition and the concentration of serum antibodies. Signal intensitybased antibody binding profiles measured with random-sequence peptide microarrays attempt to capture these changes to render them applicable to serological diagnostics. Diagnostics based on antibody(More)