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Glucose-regulated protein 94 is the HSP90-like protein in the lumen of the endoplasmic reticulum and therefore it chaperones secreted and membrane proteins. It has essential functions in development and physiology of multicellular organisms, at least in part because of this unique clientele. GRP94 shares many biochemical features with other HSP90 proteins,(More)
BACKGROUND mTOR kinase forms the mTORC1 complex by associating with raptor and other proteins and affects a number of key cell functions. mTORC1 activates p70S6kinase 1 (p70S6K1) and inhibits 4E-binding protein 1 (4E-BP1). In turn, p70S6K1 phosphorylates a S6 protein of the 40S ribosomal subunit (S6rp) and 4E-BP1, with the latter negatively regulating(More)
are highly sensitive to selective inhibition of CDK4 kinase activity Mantle cell lymphoma cells express predominantly Cyclin D1a isoform and (4217 articles) Neoplasia (231 articles) Cell Cycle Articles on similar topics can be found in the following Blood collections Information about subscriptions and ASH membership may be found online at: digital object(More)
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