Michal Hoffmann

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In recent years, sedating antidepressants have been increasingly used to treat primary insomnia. Up to now, only one open pilot study with trimipramine and one double-blind placebo-controlled study with doxepin have provided scientific support for this approach in treating primary insomnia. In order to test the hypothesis that sedating antidepressants are(More)
AIMS We tested whether characteristic changes of the plasma lipidome in individuals with comparable total lipids level associate with future cardiovascular disease (CVD) outcome and whether 23 validated gene variants associated with coronary artery disease (CAD) affect CVD associated lipid species. METHODS AND RESULTS Screening of the fasted plasma(More)
We evaluated the association of indices of paraoxonase (PON1) and oxidative status with subclinical cardiovascular disease (CVD) in mixed-ancestry South Africans. Participants were 491 adults (126 men) who were stratified by diabetes status and body mass index (BMI). Carotid intima-media thickness (CIMT) was used as a measure of subclinical CVD. Indices of(More)
Impairment of well-being and cognitive function has been reported in growth hormone-deficient adults, as well as an improvement of these parameters after GH substitution, albeit inconsistently. The effect of growth hormone on central nervous activity, vigilance and sleepiness was studied prospectively in 16 growth hormone-deficient adults (7 females, 9(More)
  • Arias A, Corbella M, Fons C, Sempere A, García Villoria, Ormazábal A +34 others
  • 2010
transporter deficiency: prevalence among patients with mental retardation and pitfalls in metabolite screening. Factor impacte: 0,736 Campistol J. Enfermedades neurometabólicas de presentación neonatal como causantes de trastornos del neurodesarrollo. Intracranial pressure and cerebral perfusion pressure as risk factors in children with traumatic brain(More)
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