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PURPOSE To quantify periodic displacement in the cranium using complementary spatial modulation of magnetization (CSPAMM) with harmonic phase (HARP) postprocessing. MATERIALS AND METHODS CSPAMM tagging sequence with separate tag-line preparation in two orthogonal directions was applied on 10 healthy volunteers in combination with HARP for tissue(More)
Pulsatile brain motion is considered to be an important mechanical link between blood and cerebrospinal fluid (CSF) dynamics. Like many severe brain diseases, different types of hydrocephalus are associated with impairment of these dynamics. In this work a cine displacement-encoded imaging method employing stimulated echoes (DENSE) and a three-dimensional(More)
It has been suggested recently that the influence of the neuro-magnetic field should make electrical brain activity directly detectable by MRI. To test this hypothesis, we performed combined EEG-MRI experiments which aim to localize the neuronal current sources of alpha waves (8-12 Hz), one of the most prominent EEG phenomena in humans. A detailed analysis(More)
BACKGROUND AND PURPOSE Quantitative MR imaging techniques allow detection of subtle tissue changes that occur with brain aging beyond the accumulation of WMH and brain atrophy. To what extent sex and cerebrovascular risk factors impact these changes is largely unknown. We attempted to study these risk factors in the context of the community-based ASPS. (More)
The objective of this work is to quantify age-related differences in the characteristics and coupling of cerebral arterial inflow and cerebrospinal fluid (CSF) dynamics. To this end, 3T phase-contrast magnetic resonance imaging blood and CSF flow data of eleven young (24 ± 3 years) and eleven elderly subjects (70 ± 5 years) with a comparable sex-ratio were(More)
Abnormal cerebrospinal fluid (CSF) flow is suspected to be a contributor to the pathogenesis of neurodegenerative diseases such as Alzheimer's through the accumulation of toxic metabolites, and to the malfunction of intracranial pressure regulation, possibly through disruption of neuroendocrine communication. For the understanding of transport processes(More)
PURPOSE To assess the state and dynamics of the intracranial system in idiopathic normal-pressure hydrocephalus (I-NPH), we determined intracranial compliance using magnetic resonance imaging (MRI). MATERIALS AND METHODS The intracranial compliance index (ICCI), which was defined as the ratio of the peak-to-peak intracranial volume change (ICVC(p-p)) to(More)
The cerebrospinal fluid flow in the third ventricle of the brain and the aqueduct of Sylvius was studied using computational fluid dynamics (CFD) based on subject-specific boundary conditions derived from magnetic resonance imaging (MRI) scans. The flow domain geometry was reconstructed from anatomical MRI scans by manual image segmentation. The movement of(More)
A finite-volume model of the cerebrospinal fluid (CSF) system encompassing the third ventricle and the aqueduct of Sylvius was used to reconstruct CSF velocity and pressure fields based on MRI data. The flow domain geometry was obtained through segmentation of MRI brain anatomy scans. The movement of the domain walls was interpolated from brain motion MRI(More)
This study aims at investigating three-dimensional subject-specific cerebrospinal fluid (CSF) dynamics in the inferior cranial space, the superior spinal subarachnoid space (SAS), and the fourth cerebral ventricle using a combination of a finite-volume computational fluid dynamics (CFD) approach and magnetic resonance imaging (MRI) experiments. An(More)