Michaela Conrad

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The yeast Saccharomyces cerevisiae has been a favorite organism for pioneering studies on nutrient-sensing and signaling mechanisms. Many specific nutrient responses have been elucidated in great detail. This has led to important new concepts and insight into nutrient-controlled cellular regulation. Major highlights include the central role of the Snf1(More)
Two nutrient-controlled signalling pathways, the PKA and TOR pathway, play a major role in nutrient regulation of growth as well as growth-correlated properties in yeast. The relationship between the two pathways is not well understood. We have used Gap1 and Pho84 transceptor-mediated activation of trehalase and phosphorylation of fragmented Sch9 as a(More)
RGD peptides are known as important ligands for integrin receptors in the cell adhesion process. The selectivity of RGD peptides for a certain integrin receptor is partly dependent on the RGD conformation and the residues surrounding the RGD sequence. This paper investigates the effect of the addition of a phenylalanine residue on the RGD conformation in(More)
In the yeast Saccharomyces cerevisiae several nutrient transporters have been identified that possess an additional function as nutrient receptor. These transporters are induced when yeast cells are starved for their substrate, which triggers entry into stationary phase and acquirement of a low protein kinase A (PKA) phenotype. Re-addition of the lacking(More)
A 10 amino acid residue cyclic peptide, cyclo(2,9)-Ac-Gln1-Cys2-Arg3-Ser4-Val5-Glu6-Gly7 -Ser8-Cys9-Gly10, from the C-terminal region of human growth hormone (hGH) was synthesized and studied by 2D proton NMR and molecular dynamics (MD) simulations. The solubility of the peptide was low in water; hence, NMR studies were done in two solvent mixtures, water(More)
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