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The aging process in the hippocampus is associated with aberrant epigenetic marks, such as DNA methylation and histone tail alterations. Recent evidence suggests that caloric restriction (CR) can potentially delay the aging process, while upregulation of antioxidants may also have a beneficial effect in this respect. We have recently observed that CR(More)
Many studies have used test batteries for the evaluation of affective behavior in rodents. This has the advantage that treatment effects can be examined on different aspects of the affective domain. However, the behavior in one test may affect the behavior in following test. The present study examined possible order effects in rats that were tested in three(More)
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