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This study extends our earlier studies in rats by applying our heatstroke model to a new species. Additionally, transgenic mice are used to examine the role of heat shock protein (HSP) 72 in experimental heatstroke. Transgenic mice that were heterozygous for a porcine HSP70i gene ([+]HSP72), transgene-negative littermate controls ([-]HSP72), and normal(More)
PURPOSE To evaluate by means of high-resolution CT the anatomic variations of the middle cranial fossa foramen. METHODS We examined 123 CT studies of the temporal bone in patients with no evidence of disease that might alter foraminal anatomy. A checklist of known variants and suspected structures was used as each case was systematically examined for the(More)
Five patients with Sturge-Weber syndrome were evaluated by conventional noncontrast spin-echo MR imaging, a gradient-recalled echo (GRE) technique, and T1-weighted spin-echo imaging after administration of gadopentetate dimeglumine. In four of five cases the full extent of intracranial disease was appreciated only on the postcontrast images. In one patient(More)
PURPOSE To assess the risks and implications of assuming that white matter lesions in cancer patients that do not enhance with gadopentetate dimeglumine (Gd-DTPA) can be considered to be benign. METHODS Gd-DTPA was administered prospectively to 131 consecutive patients with biopsy-proved extracranial malignancies referred for cranial MR imaging to exclude(More)
OBJECTIVE To investigate whether the effects of sex (male/female) that have been demonstrated in the pathology literature using 0.1 mm histopathologic slices are measurable and statistically significant using high-resolution (0.625 mm slice) computed tomography (CT). METHODS IRB-approved retrospective analysis of high-resolution "normal" CT temporal bone(More)
This paper proposes an efficient method for automatically segmenting vessels from angiogram sequences. The method includes two steps: extracting high-contrast angiograms and segmenting vessels. First, we select high-contrast angiograms automatically using vessel intensity distribution. Based on multiscale Hessian-based filtering, we propose an adaptive(More)
PURPOSE Prior studies have associated gross inner ear abnormalities with pediatric sensorineural hearing loss (SNHL) using computed tomography (CT). No studies to date have specifically investigated morphologic inner ear abnormalities involving the contralateral unaffected ear in patients with unilateral SNHL. The purpose of this study is to evaluate(More)
Increased volume and density of the skull makes computed tomography differentiation of gray and white matter (GM and WM, respectively) more difficult. The purpose of this investigation was to study the effects of skull volume and bone density on GM and WM differentiation. A total of 21 patients with thick skulls and 22 controls were included in this study.(More)
Dilated venous channels traversing the sella and connecting the two cavernous sinuses were seen on contrast-enhanced MR images in four patients with angiographically proved carotid fistulas. The anatomy and variations of these so-called intercavernous sinuses are discussed and are demonstrated in Latex-injected anatomic specimens. Direct visualization of(More)