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Fluorescent proteins (FPs) emitting in the far-red region of the spectrum are highly advantageous for whole-body imaging applications because scattering and absorption of long-wavelength light is markedly reduced in tissue. We characterized variants of the red fluorescent protein eqFP611 with bright fluorescence emission shifted up to 639 nm. The additional(More)
Lewy bodies, alpha-synuclein (alpha-syn) immunopositive intracellular deposits, are the pathological hallmark of Parkinson's disease (PD). Interestingly, Lewybody-like structures have been identified in fetal tissue grafts about one decade after transplantation into the striatum of PD patients. One possible explanation for the accelerated deposition of(More)
  • Simone Kredel, Franz Oswald, Karin Nienhaus, Karen Deuschle, Carlheinz Röcker, Michael Wolff +3 others
  • 2009
A monomeric variant of the red fluorescent protein eqFP611, mRuby, is described. With excitation and emission maxima at 558 nm and 605 nm, respectively, and a large Stokes shift of 47 nm, mRuby appears particularly useful for imaging applications. The protein shows an exceptional resistance to denaturation at pH extremes. Moreover, mRuby is about ten-fold(More)
In this paper an open environment for heterogeneous system design is presented supporting all design phases. Our approach separates front-end tools with structural and behavioral modeling from back-end tools for analysis , simulation and emulation. This separation is realized with the emerging CASE 1 data interchange format CDIF 2. Though CDIF is intended(More)
Prior research has found mixed results regarding the performance impact of chief information officers (CIOs) included on top management teams (TMTs). This study answers the question, under which circumstances firms should include IT responsibility in the TMT and how to integrate IT in the TMT to successfully enhance firm financial performance. We explain(More)
Low back pain with resultant loss of function, decreased productivity, and high economic costs is burdensome for both the individual and the society. Evidence suggests that intervertebral disc pathology is a major contributor to spine-related pain and degeneration. When commonly used conservative therapies fail, traditional percutaneous or surgical options(More)
  • S R Lewis, L R Steele, J A Holmes, Patel, M R, David Kass +5 others
  • 2016
Copyright and Moral Rights for the articles on this site are retained by the individual authors and/or other copyright owners. For more information on Open Research Online's data policy on reuse of materials please consult the policies page. Introduction The technique of data assimilation is employed in a novel way for a planetary atmosphere to perform a(More)
Follicle flushing has been proved to be ineffective in polyfollicular in vitro fertilization. To analyze the effect of flushing in monofollicular in vitro fertilization we aspirated and then flushed the follicles in 164 cycles. Total oocyte yield/aspiration was 44.5% in the aspirate, 20.7% in the 1(st) flush, 10.4% in the 2(nd) flush and 4.3% in the 3(rd)(More)