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Although extensive data support a central pathogenic role for amyloid beta protein (Abeta) in Alzheimer's disease, the amyloid hypothesis remains controversial, in part because a specific neurotoxic species of Abeta and the nature of its effects on synaptic function have not been defined in vivo. Here we report that natural oligomers of human Abeta are(More)
Accumulation of the amyloid-beta protein (Abeta) in the cerebral cortex is an early and invariant event in the pathogenesis of Alzheimer's disease. The final step in the generation of Abeta from the beta-amyloid precursor protein is an apparently intramembranous proteolysis by the elusive gamma-secretase(s). The most common cause of familial Alzheimer's(More)
Subdividing the iteration space of a loop into blocks or <italic>tiles</italic> with a fixed maximum size has several advantages. Tiles become a natural candidate as the unit of work for parallel task scheduling. Synchronization between processors can be done between tiles, reducing synchronization frequency (at some loss of potential parallelism). The(More)
Constitutive NOTCH signaling in lymphoid progenitors promotes the development of immature T-cell lymphoblastic neoplasms (T-ALLs). Although it is clear that Notch signaling can initiate leukemogenesis, it has not previously been established whether continued NOTCH signaling is required to maintain T-ALL growth. We demonstrate here that the blockade of Notch(More)
Dependence graphs can be used as a vehicle for formulating and implementing compiler optimizations. This paper defines such graphs and discusses two kinds of transformations. The first are simple rewriting transformations that remove dependence arcs. The second are abstraction transformations that deal more globally with a dependence graph. These(More)
Presenilins mediate an unusual intramembranous proteolytic activity known as gamma-secretase, two substrates of which are the Notch receptor (Notch) and the beta-amyloid precursor protein (APP). Gamma-secretase-mediated cleavage of APP, like that of Notch, yields an intracellular fragment [APP intracellular domain (AICD)] that forms a transcriptively active(More)
The PGI Accelerator model is a high-level programming model for accelerators, such as GPUs, similar in design and scope to the widely-used OpenMP directives. This paper presents some details of the design of the compiler that implements the model, focusing on the <i>Planner</i>, the element that maps the program parallelism onto the hardware parallelism.