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The Human Metabolome Database (HMDB) (www.hmdb.ca) is a resource dedicated to providing scientists with the most current and comprehensive coverage of the human metabolome. Since its first release in 2007, the HMDB has been used to facilitate research for nearly 1000 published studies in metabolomics, clinical biochemistry and systems biology. The most(More)
DrugBank (http://www.drugbank.ca) is a comprehensive online database containing extensive biochemical and pharmacological information about drugs, their mechanisms and their targets. Since it was first described in 2006, DrugBank has rapidly evolved, both in response to user requests and in response to changing trends in drug research and development.(More)
Metabolomics is increasingly being applied towards the identification of biomarkers for disease diagnosis, prognosis and risk prediction. Unfortunately among the many published metabolomic studies focusing on biomarker discovery, there is very little consistency and relatively little rigor in how researchers select, assess or report their candidate(More)
The feature or service interaction problem within home networks is an established topic for the FI community. Interactions between home appliances, services and their environment have been reported previously. Indeed earlier work by the authors introduced a device centric approach which detects undesirable behaviour between appliances and their effects on(More)
In the near future general household appliances such as televisions, refrigerators, alarm clocks, stoves, and even lights, will be supplemented with a network interface connecting the appliance to the Internet. Homes are being equipped with such networked appliances to allow a more convenient way of living. Such extensive automatic control of appliances(More)
The Yeast Metabolome Database (YMDB, http://www.ymdb.ca) is a richly annotated 'metabolomic' database containing detailed information about the metabolome of Saccharomyces cerevisiae. Modeled closely after the Human Metabolome Database, the YMDB contains >2000 metabolites with links to 995 different genes/proteins, including enzymes and transporters. The(More)
Urine has long been a "favored" biofluid among metabolomics researchers. It is sterile, easy-to-obtain in large volumes, largely free from interfering proteins or lipids and chemically complex. However, this chemical complexity has also made urine a particularly difficult substrate to fully understand. As a biological waste material, urine typically(More)
BACKGROUND Lateral roots are formed at regular intervals along the main root by recurrent specification of founder cells. To date, the mechanism by which branching of the root system is controlled and founder cells become specified remains unknown. RESULTS Our study reports the identification of the auxin regulatory components and their target gene,(More)
CFM-ID is a web server supporting three tasks associated with the interpretation of tandem mass spectra (MS/MS) for the purpose of automated metabolite identification: annotation of the peaks in a spectrum for a known chemical structure; prediction of spectra for a given chemical structure and putative metabolite identification--a predicted ranking of(More)
Seven precompetitive research projects on user interfaces in Europe are described. The projects considered are Hufit, the Comett I Project, the Elusive Office Project, the Euroworkstation Project, Acord, MMI/sup 2/, and Xtra. The integration of user interface technologies into new application tasks and the integration of new techniques and artifacts into(More)