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An exploration of ambigrammatic sequences in narnaviruses
TLDR
It is shown that only when the codon frames are aligned can all stop codons be eliminated from the reverse strand by synonymous single-nucleotide substitutions in the RdRp gene, suggesting a mechanism for de novo gene creation within a strongly conserved amino-acid sequence.
Terasaki Spiral Ramps and Intracellular Diffusion
The sheet-like endoplasmic reticulum (ER) of eukaryotic cells has been found to be riddled with spiral dislocations, known as ‘Terasaki ramps’, in the vicinity of which the doubled bilayer membranes
An exploration of ambigrammatic sequences in narnaviruses
TLDR
It is shown that only when the codon frames are aligned can all stop codons be eliminated from the reverse strand by synonymous single-nucleotide substitutions in the RdRp gene, suggesting a mechanism for de novo gene creation within a strongly conserved amino-acid sequence.
Polysomally protected viruses.
TLDR
It is argued that in the type 2 case the viral RNA would evolve an ambigrammatic property, whereby the viral genes are free of stop codons in a reverse reading frame (with forward and reverse codons aligned), which is consistent with recent observations of ribosome profiles of ambigramsmatic narnavirus sequences.
Terasaki spiral ramps and intracellular diffusion.
The sheet-like endoplasmic reticulum (ER) of eukaryotic cells has been found to be riddled with spiral dislocations, known as 'Terasaki ramps', in the vicinity of which the doubled bilayer membranes
Polymorphism of genetic ambigrams
TLDR
Analysis of Robin polymorphisms suggests that its reverse open reading frame also does not code for a functional protein, suggesting that its role in ambigrammatic narnavirus genomes is unclear.
Persistent Features of Intermittent Transcription
TLDR
Analysis of correlations between mRNA gene counts finds strong evidence that when genes are only observed in a small fraction of cells, this is as a consequence of intermittent transcription rather than of expression only in specialized cell types.
Persistent features of intermittent transcription
TLDR
A novel parametrisation of sc-RNA data is introduced, giving estimates of the probability of activation of a gene and its peak transcription rate, which are agnostic about the mechanism underlying the fluctuations in the counts.
Polymorphism of Genetic Ambigrams
TLDR
Analysis of Robin polymorphisms suggests that the reverse open reading frame of the segment coding for RNA-dependent RNA polymerase does not code for a functional protein.