Michael Westhoff

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Der zunehmende Stellenwert der nichtinvasiven Beatmung (NIV) in der Therapie der akuten respiratorischen Insuffizienz (ARI) ist durch klinische Studien untermauert. Eine neue S3-Leitlinie macht das evidenzbasierte Wissen über Indikationen und Grenzen der NIV bei ARI in der Praxis verfügbar. An der Entwicklung der Leitlinie beteiligten sich 28 Experten aus(More)
BACKGROUND Analysis of exhaled breath, especially of volatile organic compounds (VOCs), is of increasing interest in the diagnosis of lung cancer. Compared with other methods of breath analysis, ion mobility spectrometry (IMS) offers a tenfold higher detection rate of VOCs. By coupling the ion mobility spectrometer with a multicapillary column as a(More)
Mechanical ventilation is the essential treatment for acute respiratory failure. The methods used differ greatly depending on whether one chooses invasive or noninvasive. Noninvasive ventilation avoids orotracheal intubation, facilitates weaning and, if negative pressure ventilation is integrated with positive pressure ventilation, the majority of patients(More)
A feasibility study with ion mobility spectrometry (IMS) was started to find characteristic peaks of volatile organic compounds in exhaled air of 10 mL sampling volume, which might be relevant for the diagnosis of sarcoidosis. Therefore, breath samples of 9 patients with sarcoidosis and suspicion of sarcoidosis because of mediastinal lymph node enlargement(More)
Hinter der Bezeichnung 1zentrale Schlafapnoe“ verbergen sich verschiedene Syndrome unter− schiedlicher Genese und damit auch unter− schiedlicher klinischer Wertigkeit und Therapie− bedürftigkeit. Diese CME−Fortbildung zur zentra− len Schlafapnoe basiert auf einem Übersichtsarti− kel der Arbeitsgruppe Pathophysiologie Schlaf/ Atmung der Deutschen(More)
A feasibility study using an ion mobility spectrometer coupled with a multi-capillary column (MCC) was started to identify characteristic peaks of volatile compounds in exhaled human breath samples of 10 ml volume. The breath of 20 patients with sarcoidosis and suspicion of sarcoidosis because of mediastinal lymph node enlargement was investigated. Using a(More)
This document replaces the DGP recommendations published in 1998. Based on recent studies and a consensus conference, the indications, choice and performance of the adequate exercise testing method in its necessary technical and staffing setting are discussed. Detailed recommendations are provided: for arterial blood gas analysis and right heart(More)
INTRODUCTION Non-invasive mechanical ventilation (NIV) has been used to treat acute respiratory failure (ARF) for approximately 20 years. This guideline addresses the indications for, and limitations of, NIV as treatment for ARF according to evidence-based criteria. METHODS A panel of experts from 12 scientific medical societies reviewed circa 2900(More)
This study aimed to assess the prevalence of complex sleep apnoea (CompSA), defined as central sleep apnoea (CSA) emerging after the initiation of continuous positive airway pressure (CPAP) therapy for obstructive sleep apnoea (OSA), in patients with normal brain natriuretic peptide (BNP) levels, along with assessing the prevalence of CSA persisting in such(More)
The human breath contains indicators of human health and delivers information about different metabolism processes of the body. The detection and attribution of these markers provide the possibility for new, non-invasive diagnostic methods. In the recent study, ion mobility spectrometers are used to detect different volatile organic metabolites in human(More)