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Reconstruction and Simulation of Neocortical Microcircuitry
UNLABELLED We present a first-draft digital reconstruction of the microcircuitry of somatosensory cortex of juvenile rat. The reconstruction uses cellular and synaptic organizing principles toExpand
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A Biophysically Detailed Model of Neocortical Local Field Potentials Predicts the Critical Role of Active Membrane Currents
Brain activity generates extracellular voltage fluctuations recorded as local field potentials (LFPs). It is known that the relevant microvariables, the ionic currents across membranes, jointlyExpand
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Cliques of Neurons Bound into Cavities Provide a Missing Link between Structure and Function
TLDR
The lack of a formal link between neural network structure and its emergent function has hampered our understanding of how the brain processes information. Expand
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The neocortical microcircuit collaboration portal: a resource for rat somatosensory cortex
TLDR
We have established a multi-constraint, data-driven process to digitally reconstruct, and simulate prototypical neocortical microcircuitry, using sparse experimental data. Expand
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An algorithm to predict the connectome of neural microcircuits
TLDR
We present a theoretical framework and a data-driven algorithm to digitally reconstruct the complete synaptic connectivity between the different types of neurons in a small well-defined volume of tissue. Expand
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Automated point-neuron simplification of data-driven microcircuit models
TLDR
A method is presented for the reduction of morphologically detailed microcircuit models to a point-neuron representation without human intervention, and can be continuously updated as the latter iteratively integrates new data. Expand
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Topological analysis of the connectome of digital reconstructions of neural microcircuits
A recent publication provides the network graph for a neocortical microcircuit comprising 8 million connections between 31,000 neurons. Since traditional graph-theoretical methods may not beExpand
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Rich cell-type-specific network topology in neocortical microcircuitry
TLDR
We found a small-world topology with an average of 2.5 synapses separating any two cells and multiple cell-type-specific wiring features. Expand
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Morphological Diversity Strongly Constrains Synaptic Connectivity and Plasticity
Synaptic connectivity between neurons is naturally constrained by the anatomical overlap of neuronal arbors, the space on the axon available for synapses, and by physiological mechanisms that formExpand
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