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  • J. -P. Stasch, Peter Frederick Schmidt, +13 authors Frank Wunder
  • Chemistry, Medicine
  • British journal of pharmacology
  • 2002 (First Published: 1 July 2002)
  • 1. Soluble guanylyl cyclase (sGC) is the only proven receptor for the ubiquitous biological messenger nitric oxide (NO) and is intimately involved in many signal transduction pathways, most notablyContinue Reading
  • Peter Ellinghaus, Iring Heisler, +11 authors Karl B Ziegelbauer
  • Biology, Medicine
  • Cancer medicine
  • 2013 (First Published: 1 August 2013)
  • The activation of the transcription factor hypoxia-inducible factor-1 (HIF-1) plays an essential role in tumor development, tumor progression, and resistance to chemo- and radiotherapy. In order toContinue Reading
  • Frank Wunder, Hanna Tinel, +6 authors Michael W. Härter
  • Chemistry, Medicine
  • British journal of pharmacology
  • 2010 (First Published: 1 May 2010)
  • BACKGROUND AND PURPOSE Cysteinyl leukotrienes (CysLTs) have been implicated in the pathophysiology of inflammatory and cardiovascular disorders. Their actions are mediated by CysLT(1) and CysLT(2)Continue Reading
  • Uwe Muenster, Wolfgang Mueck, +8 authors Andreas Ohm
  • Chemistry, Medicine
  • European journal of pharmaceutics and…
  • 2016 (First Published: 1 May 2016)
  • The purpose of the study was to experimentally deduce pH-dependent critical volumes to dissolve applied dose (VDAD) that determine whether a drug candidate can be developed as immediate release (IR)Continue Reading