Michael W. Best

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Neurocognitive impairments are observed in depression and associated with poor functioning. This study examined the efficacy and the effectiveness of cognitive remediation with supplemental Internet-based homework in treatment-resistant depression. Participants were randomized to treatment or wait list control conditions. Treatment consisted of 10 weeks of(More)
BACKGROUND Many individuals with schizophrenia experience remission of prominent positive symptoms but continue to experience impairments in real world functioning. Residual negative and depressive symptoms may have a direct impact on functioning and impair patients' ability to use the cognitive and functional skills that they possess (competence) in the(More)
Stigma towards individuals diagnosed with schizophrenia continues despite increasing public knowledge about the disorder. Questionnaires are used almost exclusively to assess stigma despite self-report biases affecting their validity. The purpose of this experiment was to implicitly assess stigma towards individuals with schizophrenia by measuring visual(More)
Treatment-resistant depression (TRD) refers to a condition where individuals with major depressive disorder have inadequate or no response to treatment. Although functional disability is a prominent and costly feature of treatment resistance, very little is known about the factors that contribute to and maintain functional impairment in TRD. This is the(More)
OBJECTIVE Cognitive remediation programs often have larger effects on cognition compared with everyday outcomes. We compared changes across cognitive, functional competence, and vocational domains in 2 cognitive remediation programs. METHOD A sequential enrollment, nonrandom design with 50 individuals with serious mental illnesses (psychotic and mood(More)
AIM We examined the factor structure of the Positive and Negative Syndrome Scale (PANSS) in early-episode psychosis and its relationships with functioning at baseline and follow-up. METHODS A total of 240 consecutive admissions to an early intervention in psychosis clinic were assessed at intake to the program with the PANSS, Global Assessment of(More)
BACKGROUND The current study aimed to examine the effects of diagnostic and symptomatic information on auditory linguistic event-related potentials (ERPs) in the listener, in response to speech containing schizophrenia-associated communication abnormalities. METHODS 73 participants listened to conversation segments while continuous EEG was recorded.(More)
INTRODUCTION Schizotypy is phenologically and genetically related to schizophrenia-spectrum illness. Previous studies find cognitive function to be mildly impaired, but specific impairments and their relationship to functioning are not well understood. In this study, we sought to examine how cognitive load affects performance in schizotypy and to examine(More)
BACKGROUND Individuals with schizophrenia experience difficulty with interpersonal interactions, in part resulting from communication abnormalities that are common in the disorder, and to the expectancy effects from knowledge of the person's diagnosis. The auditory N400 event-related potential provides an objective measure of recognition of incongruent(More)
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