Michael W. Best

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Neurocognitive impairments are observed in depression and associated with poor functioning. This study examined the efficacy and the effectiveness of cognitive remediation with supplemental Internet-based homework in treatment-resistant depression. Participants were randomized to treatment or wait list control conditions. Treatment consisted of 10 weeks of(More)
PURPOSE Obstructive sleep apnea is a disabling sleep disorder characterized by obstructions or near obstructions of the upper airway. Sleep apnea shares many common features with major depressive disorder, which is a serious psychiatric disorder that can persist despite multiple treatment attempts. The current study utilizes baseline data from a study(More)
Stigma towards individuals diagnosed with schizophrenia continues despite increasing public knowledge about the disorder. Questionnaires are used almost exclusively to assess stigma despite self-report biases affecting their validity. The purpose of this experiment was to implicitly assess stigma towards individuals with schizophrenia by measuring visual(More)
BACKGROUND Many individuals with schizophrenia experience remission of prominent positive symptoms but continue to experience impairments in real world functioning. Residual negative and depressive symptoms may have a direct impact on functioning and impair patients' ability to use the cognitive and functional skills that they possess (competence) in the(More)
Treatment-resistant depression (TRD) refers to a condition where individuals with major depressive disorder have inadequate or no response to treatment. Although functional disability is a prominent and costly feature of treatment resistance, very little is known about the factors that contribute to and maintain functional impairment in TRD. This is the(More)
OBJECTIVE Cognitive remediation programs often have larger effects on cognition compared with everyday outcomes. We compared changes across cognitive, functional competence, and vocational domains in 2 cognitive remediation programs. METHOD A sequential enrollment, nonrandom design with 50 individuals with serious mental illnesses (psychotic and mood(More)
BACKGROUND Cognitive dysfunction in major depressive disorder (MDD) is identified as a primary therapeutic target; no current treatment is approved for the treatment of cognitive dysfunction in MDD. We examined whether intranasal insulin offered a beneficial effect across measures of cognitive function in adults with MDD. METHODS Thirty-five adults (18-65(More)
Among all complications of airway management, dental injury is the most common cause of patient complaints with medicolegal consequences. Over an 8-year period, data on dental injury were collected within a large university hospital system that included community, tertiary, and quaternary care centers. Patient characteristics were compared among all(More)
AIM We examined the factor structure of the Positive and Negative Syndrome Scale (PANSS) in early-episode psychosis and its relationships with functioning at baseline and follow-up. METHODS A total of 240 consecutive admissions to an early intervention in psychosis clinic were assessed at intake to the program with the PANSS, Global Assessment of(More)
BACKGROUND Individuals with schizophrenia experience difficulty with interpersonal interactions, in part resulting from communication abnormalities that are common in the disorder, and to the expectancy effects from knowledge of the person's diagnosis. The auditory N400 event-related potential provides an objective measure of recognition of incongruent(More)