Michael V. Boland

Learn More
MOTIVATION Assessment of protein subcellular location is crucial to proteomics efforts since localization information provides a context for a protein's sequence, structure, and function. The work described below is the first to address the subcellular localization of proteins in a quantitative, comprehensive manner. RESULTS Images for ten different(More)
PURPOSE To measure choroidal thickness and to determine parameters associated with it. DESIGN Cross-sectional study. PARTICIPANTS Seventy-four glaucoma patients and glaucoma suspects. METHODS Spectral domain optical coherence tomography (SD-OCT) scans were obtained to estimate average choroidal thickness in a group of glaucoma suspects and glaucoma(More)
IMPORTANCE Adherence with topical glaucoma medications is low in some patients. To identify these patients, we need more information on risk factors for nonadherence. OBJECTIVE To assess adherence with once-daily glaucoma medication. DESIGN, SETTING, AND PARTICIPANTS Prospective cohort study involving patients who were recruited from a university-based(More)
Purpose. To compare optic disc topography performed by confocal laser ophthalmoscopy in eyes with nonarteritic anterior ischemic optic neuropathy (NAION), arteritic anterior ischemic optic neuropathy (AAION), and open-angle glaucoma (OAG), adjusting for the amount of retinal ganglion cell (RGC) loss, as measured by nerve fiber layer (NFL) thickness and(More)
Decades of epidemiologic research into open-angle glaucoma have elucidated several risk factors related in some way to the disease. As more and more risk factors are identified, however, assessing their individual and collective contributions in a particular patient is becoming increasingly complicated. To help organize our knowledge of risk in glaucoma we(More)
Determination of the functions of all expressed proteins represents one of the major upcoming challenges in computational molecular biology. Since subcellular location plays a crucial role in protein function, the availability of systems that can predict location from sequence or high-throughput systems that determine location experimentally will be(More)
OBJECTIVE To assess the current state of electronic health record (EHR) use by ophthalmologists, including adoption rate and user satisfaction. DESIGN Population-based, cross-sectional study. PARTICIPANTS A total of 592 members of the American Academy of Ophthalmology (AAO) participated. METHODS A total of 3796 AAO members were randomly selected on(More)
The new field of location proteomics seeks to provide a comprehensive, objective characterization of the subcellular locations of all proteins expressed in a given cell type. Previous work has demonstrated that automated classifiers can recognize the patterns of all major subcellular organelles and structures in fluorescence microscope images with high(More)
BACKGROUND Glaucoma is an acquired degeneration of the optic nerve and a leading cause of blindness worldwide. Medical and surgical treatments that decrease intraocular pressure may prevent visual impairment and blindness. PURPOSE To compare the effectiveness of medical, laser, and surgical treatments in adults with open-angle glaucoma with regard to(More)
OBJECTIVE To assess the accuracy of using pupillary light reflex (PLR) in detecting glaucoma. CLINICAL RELEVANCE Glaucoma is a specific disease of the optic nerve and is often more severe in 1 eye. When large enough, this asymmetry in disease severity can cause a relative afferent pupillary defect (RAPD). Better detection of RAPDs may be one way to(More)