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The integrin alpha v beta 6 has been shown to be a fibronectin-binding protein. To determine whether the cytoplasmic and transmembrane domains of alpha v beta 6 are necessary for binding to fibronectin, a truncated, secreted form of the integrin lacking these domains was engineered and expressed in Chinese hamster ovary cells. Fibronectin affinity(More)
Blockade of the mitogen-activated protein (MAP) kinase pathway suppresses growth of colon cancer in vivo. Here we demonstrate a direct link between the extracellular signal-regulated kinase ERK2 and the growth-promoting cell adhesion molecule, integrin alphavbeta6, in colon cancer cells. Down-regulation of beta6 integrin subunit expression inhibits tumour(More)
Sixty-two patients with metachronous colorectal malignancies who underwent surgery at the Mayo Clinic were reviewed. Fifty per cent of the patients developed a second carcinoma within 5.5 years from the time of resection of their first tumor, and the time interval for the entire group ranged from one to 23 years. Adenomas of the colon or rectum occurred in(More)
Receptor binding and subsequent cell-mediated internalization or disassembly are the initial steps in virus replication. Cell surface molecules that participate in this process are the primary determinants of virus tissue tropism. Monoclonal antibody blockade, immunoprecipitation, and DNA transfection were used to identify decay accelerating factor as a(More)
Recent evidence suggests that integrins are involved in the multi-step process of tumour metastasis. The biological relevance of alpha(v) integrins and associated beta-subunits in ovarian cancer metastasis was examined by analysing the expression of these cell surface receptors in nine ovarian cancer cell lines and also in the primary human ovarian surface(More)
Since 1935, 42 of 103 residents of Olmsted County, Minnesota, identified as having Crohn's disease underwent one or more surgical procedures. The incidence and type of surgical intervention, distribution of disease, and risk of recurrent disease after surgery were analyzed. Follow-up extended to 32 years, with a median of 8.5 years. Thirty-six patients(More)
In human cancers, the co-operative role between cell-adhesion receptors and proteases capable of degrading matrix barriers remains poorly understood. We have previously reported that the epithelium-restricted integrin alpha(v)beta6 becomes highly expressed in colon cancer compared with normal mucosa and that heterologous expression of alpha(v)beta6 in colon(More)
Norcantharidin has been used as an efficacious anticancer drug in China for many years, but its true mechanism remains poorly understood. Intriguingly, in an in vitro series study of anticancer drugs, we found that norcantharidin can effectively inhibit epithelial tumor cells from expressing integrin alphavbeta6. Our previous studies have confirmed that(More)
Sigmoid volvulus is often a surgical emergency. The diagnosis is usually reached on the basis of both clinical and radiologic assessment. A review of the radiologic findings in 20 patients diagnosed as having sigmoid volvulus is presented. Typical radiographic features are illustrated. Reasons for their absence in certain cases are discussed. [Key words:(More)
The progression of colon cancer has been linked to both cell adhesion molecules called integrins and matrix-degrading enzymes called metalloproteinases. Herein we report that the alpha v beta 6 integrin expressed in colon cancer cells induces gelatinase B secretion through the C-terminal cytoplasmic extension unique to the beta 6 integrin subunit, and that(More)