Michael Toth

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Skeletal muscle contractile function declines with aging, disease, and disuse. In vivo muscle contractile function depends on a variety of factors, but force, contractile velocity and power generating capacity ultimately derive from the summed contribution of single muscle fibers. The contractile performance of these fibers are, in turn, dependent upon the(More)
Chronic heart failure is characterized by changes in skeletal muscle that contribute to physical disability. Most studies to date have investigated defects in skeletal muscle oxidative capacity. In contrast, less is known about how heart failure affects myofibrillar protein metabolism. Thus we examined the effect of heart failure on skeletal muscle(More)
Age-related changes in myosin heavy chain (MHC) phenotype impact both the quantity and functional character of skeletal muscle. The present study was undertaken to examine the hypothesis that age-related changes in MHC mRNA abundance underlie alterations in protein synthesis rates and content. We measured the abundance of mRNA for MHC isoforms (MHC I, MHC(More)
  • Robert J Marzano, Beverly Carbaugh, Michael Grego, Michael Toth, Report Authors
  • 2012
Leadership Evaluation promotes excellence in public education by providing and developing next-generation teacher and leadership evaluation tools and training. Built on a foundation of expert research into best practices under the direction of national researcher and author Dr. Robert Marzano, the Center identifies, develops, and disseminates cutting-edge(More)
Ecology and resource efficiency have achieved high relevance in industry, not only due to their economic effects. Thus, logistics planning is required to contribute to "green" initiatives. However, it still lacks appropriate methods and tools. Simulation represents a well-accepted method in logistics planning, for it can handle dynamics, stochastic effects(More)
Cancer cachexia contributes to poor prognosis through progressive depletion of the body's energy and protein reserves; research is revealing the impact of the quantitly of these reserves on survival. Our group has exploitated computed tomography (CT) images to study body composition in cancer patients. We argue that CT taken for the purposes of diagnosis(More)
We examined the effect of knee osteoarthritis on the rate of torque development (RTD) of the knee extensors in older adults with advanced-stage knee osteoarthritis (OA; n=15) and recreationally-active controls (n=15) of similar age, sex and health status, as well as the relationship between RTD and the size and contractility of single muscle fibers. OA(More)
Fatigue is a common symptom of numerous acute and chronic diseases, including myalgic encephalomyelitis/chronic fatigue syndrome, multiple sclerosis, heart failure, cancer, and many others. In these multi-system diseases the physiological determinants of enhanced fatigue encompass a combination of metabolic, neurological, and myofibrillar adaptations.(More)
  • Beverly Carbaugh, Edd bullet, Robert Marzano, Michael Toth, Robert J Marzano
  • 2013
Learning Sciences Marzano Center promotes excellence in public education by providing and developing next-generation teacher and leadership evaluation tools and training. Built on a foundation of expert research into best practices under the direction of national researcher and author Dr. Robert Marzano and staffed by a team of education experts, the(More)