Michael Till

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The protein folding problem studies the way in which a protein - a chain of amino acids - will 'fold' into its natural state. Predicting the way in which various proteins fold can be fundamental in developing treatments of diseases such as Alzeihmers and Systic Fibrosis. Classical solutions to calculating the final conformation of a protein structure are(More)
Most of bioinformatics data distributed on the Internet is organized in an unstructured manner, which makes it hard to construct applications that need to integrate them. In this paper, we proposed an XML schema based data indexing mechanism to integrate sequence databases stored in a DHT overlay network. The construction of large-scale distributed(More)
Summary form only given. Here we describe a new parallel program package for phylogenetic analysis of DNA sequences. This program is based on a more advanced algorithm, named advanced stepwise addition (ASA), for phylogenetic analysis using maximum likelihood approaches. There are two main advantages of our parallel program package over many existing ones.(More)
Studies from our laboratory have previously shown that two opioid agonists (morphine and [D-Met2,Pro5]enkephalinamide) aggravate, whereas naloxone inhibits cold-restraint stress-induced ulceration in rats. In the present study the effects of these substances were examined using the Shay-model. Contrary to expectations, both naloxone and the opioid agonists(More)
The aim of the present investigation was to examine which areas of the brain might mediate the anti-apomorphine action of some opioids, which were found previously to be active upon subcutaneous application. As the first step, the substances were injected intracerebroventricularly or into the nucleus accumbens, a mesolimbic region which is rich in dopamine,(More)
The effects of D-Met2, Pro5-enkephalinamide (EA) on pain tolerance and some cognitive functions have been examined in healthy male volunteers. Dihydrocodeine (DC) was used as reference substance. Applying the submaximum effort tourniquet technique EA (10 mg SC) was found to elevate the pain threshold similarly to DC (20 mg SC). Neither DC nor EA impaired(More)
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