Michael Thomson

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MOTIVATION Recent evidence shows significant involvement of microRNAs (miRNAs) in the initiation and progression of numerous cancers; however, the role of these in tumor drug resistance remains unknown. RESULTS By comparing global miRNA and mRNA expression patterns, we examined the role of miRNAs in resistance to the 'pure antiestrogen' fulvestrant, using(More)
Estradiol (E2) regulates gene expression at the transcriptional level by functioning as a ligand for estrogen receptor alpha (ERalpha) and estrogen receptor beta (ERbeta). E2-inducible proteins c-Myc and E2Fs are required for optimal ERalpha activity and secondary estrogen responses, respectively. We show that E2 induces 21 microRNAs and represses seven(More)
A parameterized model for resonant clocking inductors embedded in a dense power grid was developed using extensive electromagnetic simulations. The resulting model was used to support resonant clock designs for the POWER8<sup>TM</sup> microprocessor. The model enabled tuning of the inductance attached to each clock sector to optimize its resonant behavior,(More)
Improvised explosive devices (IEDs) are a major threat to coalition troops in recent asymmetric conflicts such as Afghanistan. Soldiers still rely heavily on their own senses to detect and assess IED threats, requiring good IED awareness training methods. Three prototype training tools developed for the Canadian Forces are presented here as a "blended"(More)
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