Michael Thommen

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The molecular machinery of life relies on complex multistep processes that involve numerous individual transitions, such as molecular association and dissociation steps, chemical reactions, and mechanical movements. The corresponding transition rates can be typically measured in vitro but not in vivo. Here, we develop a general method to deduce the in-vivo(More)
In this thesis the development of chiral amino alcohols and amino sulfides for the transitionmetal catalyzed asymmetric transfer hydrogenation of aromatic ketones is described and the origin of the enantioselectivity is studied. The first enantioselective reduction of aromatic 2H-azirines is reported. The Ru(arene)[(1S, 3R,(More)
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