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The clinical development of an inhibitor of cellular proteasome function suggests that compounds targeting other components of the ubiquitin-proteasome system might prove useful for the treatment of human malignancies. NEDD8-activating enzyme (NAE) is an essential component of the NEDD8 conjugation pathway that controls the activity of the cullin-RING(More)
Clarens is a Grid-enabled web service infrastructure implemented to augment the current batch-oriented Grid services computing model in the Compound Muon Solenoid (CMS) experiment of the LHC. Clarens servers leverage the Apache web server to provided a scalable framework for clients to communicate with services using the SOAP and XML-RPC protocols. This(More)
The use of meta-schedulers for resource management in large-scale distributed systems often leads to a hierarchy of schedulers. In this paper, we discuss why existing meta-scheduling hierarchies are sometimes not sufficient for Grid systems due to their inability to re-organise jobs already scheduled locally. Such a job re-organisation is required to adapt(More)
BACKGROUND Ramucirumab is a human IgG1 monoclonal antibody that targets the extracellular domain of VEGFR-2. We aimed to assess efficacy and safety of treatment with docetaxel plus ramucirumab or placebo as second-line treatment for patients with stage IV non-small-cell-lung cancer (NSCLC) after platinum-based therapy. METHODS In this multicentre,(More)
BACKGROUND There is controversy whether patients diagnosed with large-cell neuroendocrine carcinoma (LCNEC) should be treated according to protocols for non-small cell lung cancers (NSCLC) or small cell lung cancers (SCLC), especially with regard to the administration of prophylactic cranial irradiation (PCI). This study was set up to determine the(More)
Twelve individuals took part in an experiment which investigated the feasibility of using physiological sensors to apply a pacing mitigation strategy to help prevent cognitive-overload-induced performance declines. The participants performed tasks using a simulated Tactical Tomahawk Weapons Control System (TTWCS) while wearing electroencephalograph (EEG),(More)
Linear and non-linear classifiers provide different strengths for evaluating neurophysiological sensor data. The dynamic nature and non-linear trends of neurophysiological data would appear suited to the use of a non-linear classifier such as an artificial neural network. A research team explored the application of both classification methods and found that(More)
This paper describes progress made in the development of the Clarens Web Services Framework, including a second Java-based server implementation, improved performance , a global lookup and discovery service leveraging of the MonALISA monitoring system, and adapting the framework to a secure message-based transport protocol.
In this paper we describe JClarens; a Java based implementation of the Clarens remote data server. JClarens provides web services for an interactive analysis environment to dynamically access and analyze the tremendous amount of data scattered across various locations. Additionally this research is aimed to develop a service oriented Grid Enabled Portal(More)
The concept of coupling geographically distributed resources for solving large scale problems is becoming increasingly popular forming what is popularly called grid computing. Management of resources in the Grid environment becomes complex as the resources are geographically distributed , heterogeneous in nature and owned by different individuals and(More)