Michael Terman

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BACKGROUND We investigated a possible mechanism of action for the antidepressant response to light-phase advances of the circadian clock-by measuring the onset of melatonin secretion before and after light treatment in the morning or evening. METHODS Plasma melatonin was sampled in 42 patients with seasonal affective disorder, in the evening or overnight(More)
Bright light therapy for seasonal affective disorder (SAD) has been investigated and applied for over 20 years. Physicians and clinicians are increasingly confident that bright light therapy is a potent, specifically active, nonpharmaceutical treatment modality. Indeed, the domain of light treatment is moving beyond SAD, to nonseasonal depression (unipolar(More)
Restricted daily feeding schedules result in the partial or complete synchronization of a wide range of rhythmic biological functions in rodents. In some cases, exemplified by drinking behavior and liver tyrosine transaminase activity, this represents primarily a direct, exogenous influence of food intake. In others, synchronization is achieved by(More)
The Seasonal Pattern Assessment Questionnaire (SPAQ) was mailed to a sample population balanced for sex and randomly selected from local telephone directories in four areas: Nashua, NH, New York, NY, Montgomery County, MD, and Sarasota, FL. On the basis of responses to this questionnaire, prevalence rates of winter seasonal affective disorder (winter SAD),(More)
BACKGROUND Artificial bright light presents a promising nonpharmacological treatment for seasonal affective disorder. Past studies, however, have lacked adequate placebo controls or sufficient power to detect group differences. The importance of time of day of treatment--specifically, morning light superiority--has remained controversial. METHODS This(More)
Bright artificial light has been found effective in reducing winter depressive symptoms of Seasonal Affective Disorder, although conclusions about the true magnitude of treatment effect and importance of time of day of light exposure have been limited by methodologic problems. Individual subjects' data from 14 research centers studying 332 patients over 5(More)
BACKGROUND Bright light therapy was shown to be a promising treatment for depression during pregnancy in a recent open-label study. In an extension of this work, we report findings from a double-blind placebo-controlled pilot study. METHOD Ten pregnant women with DSM-IV major depressive disorder were randomly assigned from April 2000 to January 2002 to a(More)
Feeding and drinking behavior of rats maintained in constant light were recorded before, during and after feeding schedules with periods lying within or outside the range of circadian entrainment. Regardless of period, all schedules immediately resulted in the partial or complete synchronization of drinking behavior, but failed to entrain the free-running(More)
OBJECTIVE The authors' goal was to determine whether the pattern and severity of depressive symptoms predict response to light treatment for seasonal affective disorder. METHOD Subjects with winter depression (N = 103) were given bright light treatment. Seventy-one were classified as responders, 15 as nonresponders, and 17 as partial responders. Using(More)
The Committee on Chronotherapeutics, delegated by the International Society for Affective Disorders (ISAD), makes the following recommendations after reviewing the evidence as of November 2004. (1) Wake therapy is the most rapid antidepressant available today: approximately 60% of patients, independent of diagnostic subtype, respond with marked improvement(More)