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Objective-Summary measures of population health are statistics that combine mortality and morbidity to represent overall population health in a single index. Such measures include healthy life expectancy, also called disability-free life expectancy and active life expectancy. Healthy life expectancy can be calculated using cross-sectional or longitudinal(More)
Microarray expression data is being generated by the gigabyte all over the world with undoubted exponential increases to come. Annotated genomic data is also rapidly pouring into public databases. Our goal is to develop automated ways of combining these two sources of information to produce insight into the operation of cells under various conditions. Our(More)
The imbalance between energy intake and expenditure is the underlying cause of the current obesity and diabetes pandemics. Central to these pathologies is the fat depot: white adipose tissue (WAT) stores excess calories, and brown adipose tissue (BAT) consumes fuel for thermogenesis using tissue-specific uncoupling protein 1 (UCP1). BAT was once thought to(More)
Environmental factors during early life are critical for the later metabolic health of the individual and of future progeny. In our obesogenic environment, it is of great socioeconomic importance to investigate the mechanisms that contribute to the risk of metabolic ill health. Imprinted genes, a class of functionally mono-allelic genes critical for early(More)
This report is one of several appearing as Healthy People Statistical Notes that evaluate methodological issues pertaining to summary measures. Summary measures of population health are statistics that combine mortality and morbidity to represent overall population health in a single number--in this report, health expectancy measures. This report presents a(More)
Insulin resistance is central to diabetes and metabolic syndrome. To define the consequences of genetic insulin resistance distinct from those secondary to cellular differentiation or in vivo regulation, we generated induced pluripotent stem cells (iPSCs) from individuals with insulin receptor mutations and age-appropriate control subjects and studied(More)
This report is one of several Healthy People Statistical Notes that evaluate methodological issues pertaining to summary measures - statistics that combine mortality and morbidity data to represent overall population health in a single number. This report evaluates the consequences of changes in the components of health expectancy measures (i.e., mortality(More)
Objective-Life expectancy without activity limitations or active life expectancy is one of the health expectancy measures that is used to summarize population health. The measure differentiates the remaining years of life that are expected to be spent with activity limitations from expected years of life without activity limitations. The objective of this(More)
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