Michael T. McCormick

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BACKGROUND Vessel dilator, a 37-amino acid peptide hormone synthesized in the heart, enhances urine flow 4- to 12-fold and sodium excretion 3- to 6-fold in healthy humans. The present investigation was designed to determine whether vessel dilator might have similar beneficial effects in persons with congestive heart failure (CHF). METHODS AND RESULTS(More)
BACKGROUND Post-stroke hyperglycaemia (PSH) is associated with higher mortality and dependence, but further data on predictors of PSH and its evolution over time are required. We examined the prevalence, predictors, and prognosis of acute PSH using data from well-characterised clinical trials in the VISTA database. METHODS Data were extracted for(More)
OBJECTIVE Poststroke hyperglycemia is common and is associated with increased risk of death and dependence, but appropriate management remains uncertain. Glucose potassium insulin (GKI) infusion did not benefit patients with moderate poststroke hyperglycemia in a recent trial. Using magnetic resonance imaging (MRI), previous studies identified a(More)
C urrent acute therapies for ischemic stroke are limited. Only a small proportion of stroke patients are eligible to receive fibrinolytic therapy; clinical trials of neuroprotectant drugs have yielded disappointing results, and other potential interventions are at very early stages of development. Against this background, coordinated stroke unit care is,(More)
BACKGROUND Three peptides consisting of amino acids 1-30, 31-67, and 79-98 of the 126-amino acid atrial natriuretic factor prohormone (proANF), which have blood pressure-lowering, diuretic, natriuretic, and/or kaliuretic properties in animals, were investigated to determine if they have similar properties in humans. METHODS AND RESULTS Thirty-six healthy,(More)
BACKGROUND AND PURPOSE Insular cortex ischemia is proposed to mediate a sympathetic stimulus that leads to acute hyperglycemia after stroke. METHODS We retrospectively analyzed insular perfusion on perfusion CT (median 180 minutes after onset) in 35 patients. RESULTS We found no association of hypoperfusion (relative cerebral blood flow <0.51) with(More)
Slow and difficult communication between health care workers in Veterans Health Administration (VA) and nonVA Hospitals wastes enormous money and time and leads to inappropriate care. Three repetitive and frequent processes that exemplify this are as follows. 1) Because the VA pharmacist's verification (and sometimes rectification) of drug orders by(More)